Myeloperoxidase, modified lipoproteins, and atherogenesis

Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These fac...

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Bibliographic Details
Published in:Journal of lipid research 2009-04, Vol.50 (Suppl), p.S346-S351
Main Authors: Nicholls, Stephen J., Hazen, Stanley L.
Format: Article
Language:English
Subjects:
Animals
Atherogenesis
Atherosclerosis - immunology
Atherosclerosis - metabolism
Biocatalysis
free radicals
high density lipoprotein
Humans
Immunity, Innate - immunology
Lipoproteins - immunology
Lipoproteins - metabolism
oxidant stress
Peroxidase - immunology
Peroxidase - metabolism
scavenger receptor
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Summary:Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These factors likely contribute to clinical studies demonstrating that increased systemic levels of MPO and its oxidation products predict increased cardiovascular risk. As a result, interest has focused on the potential to target MPO for the development of new risk markers, imaging, and therapies to prevent cardiovascular events.
ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.R800086-JLR200