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The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive Evaluation

Oxidative stress (OS) arises as a consequence of an imbalance between the formation of reactive oxygen species (ROS) and the capacity of antioxidant defense mechanisms to neutralize them. Excessive ROS production can lead to the damage of critical biomolecules, such as lipids, proteins, and DNA, ult...

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Published in:International journal of molecular sciences 2023-05, Vol.24 (9), p.8368
Main Authors: Huang, Zhenzhou, Tan, Yanjie
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Language:English
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description Oxidative stress (OS) arises as a consequence of an imbalance between the formation of reactive oxygen species (ROS) and the capacity of antioxidant defense mechanisms to neutralize them. Excessive ROS production can lead to the damage of critical biomolecules, such as lipids, proteins, and DNA, ultimately contributing to the onset and progression of a multitude of diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer. Cylindromatosis (CYLD), initially identified as a gene linked to familial cylindromatosis, has a well-established and increasingly well-characterized function in tumor inhibition and anti-inflammatory processes. Nevertheless, burgeoning evidence suggests that CYLD, as a conserved deubiquitination enzyme, also plays a pivotal role in various key signaling pathways and is implicated in the pathogenesis of numerous diseases driven by oxidative stress. In this review, we systematically examine the current research on the function and pathogenesis of CYLD in diseases instigated by oxidative stress. Therapeutic interventions targeting CYLD may hold significant promise for the treatment and management of oxidative stress-induced human diseases.
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subjects Alzheimer's disease
Amino acids
Apoptosis
Arteriosclerosis
Atherosclerosis
Biomolecules
Cancer
Cardiovascular disease
Cell cycle
Cell growth
Chronic obstructive pulmonary disease
CYLD
Deubiquitinating Enzyme CYLD - genetics
Deubiquitinating Enzyme CYLD - metabolism
deubiquitination
Development and progression
disease
DNA damage
Gene expression
Genetic aspects
Health aspects
Humans
Inflammation
Kidney diseases
Kinases
Lipids
Localization
Lung diseases
Lung diseases, Obstructive
Obesity
Obstructive lung disease
Oxidation
Oxidation-Reduction
Oxidative Stress
Pathogenesis
Phosphorylation
Proteins
Reactive oxygen species
Reactive Oxygen Species - metabolism
Review
Signal Transduction
Therapeutic applications
Therapeutic targets
Traumatic brain injury
Tumorigenesis
Tumors
title The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive Evaluation
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