Recent advances of stem cell therapy for retinitis pigmentosa

Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy. Until now, the exact pathogenesis and etiology of this disease has not been clear, and many approaches for RP therapies hav...

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Bibliographic Details
Published in:International journal of molecular sciences 2014-08, Vol.15 (8), p.14456-14474
Main Authors: He, Yuxi, Zhang, Yan, Liu, Xin, Ghazaryan, Emma, Li, Ying, Xie, Jianan, Su, Guanfang
Format: Article
Language:English
Subjects:
Bone Marrow Cells - cytology
Bone Marrow Cells - physiology
bone marrow-derived mesenchymal stem cells
Eye diseases
Gene expression
Humans
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - physiology
Retina
retinitis pigmentosa
Retinitis Pigmentosa - therapy
Review
stem cell transplantation
Stem Cell Transplantation - methods
Stem cells
Transplants & implants
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Summary:Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy. Until now, the exact pathogenesis and etiology of this disease has not been clear, and many approaches for RP therapies have been carried out in animals and in clinical trials. In recent years, stem cell transplantation-based attempts made some progress, especially the transplantation of bone marrow-derived mesenchymal stem cells (BMSCs). This review will provide an overview of stem cell-based treatment of RP and its main problems, to provide evidence for the safety and feasibility for further clinical treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms150814456