A study on the relationship between waist phenotype, hypertriglyceridemia, coronary artery lesions and serum free fatty acids in adult and elderly patients with coronary diseases

• Published in: Immunity & ageing 2018-06, Vol.15 (1), p.14-14, Article 14
• Main Authors: Yang, Rui-Feng, Zhang, Hanlei, Wang, Zhongchun, Liu, Xiao-Yong, Lin, Zhi
• Format: Article
• Language: English
• Subjects: Abdomen; Age; Angina pectoris; Atherosclerosis; Blood pressure; Cardiology; Cardiovascular disease; Cardiovascular diseases; Care and treatment; Cholesterol; Complications and side effects; Coronary artery; Coronary artery disease; Coronary disease; Coronary heart disease; Coronary vessels; Development and progression; Enzyme-linked immunosorbent assay; Fatty acids; Free fatty acid; Genetic aspects; Genotype & phenotype; Geriatrics; Heart; Heart diseases; Hip; Hyperlipidemia; Hypertriglyceridemia; Hypertriglyceridemia waist phenotype; Lipids; Low density lipoprotein; Medical imaging; Metabolic syndrome; Mortality; Obesity; Patients; Phenotypes; Physiological aspects; Regression analysis; Risk factors; Thoracic surgery; Triglycerides; Waist circumference
• ISSN: 1742-4933; 1742-4933
• DOI: 10.1186/s12979-018-0119-6

Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD. We enrolled patients with coronary heart disease in our hospital from October 2008 to July 2009. Patients with high TG and increased WC, i.e. waist phenotype WP were included in group A. In group B, were included patients with high TG but not WP. Group C consisted of patients with WP but not high TG. Finally, Group D was composed of patients without high TG or WP. Serum FFA levels for all patients were measured by ELISA. The relationship between TG levels, WC, FFA levels, and coronary artery score was analysed by a single variable regression. Group A had a significantly higher FFA level than the other groups. Regression analysis showed that FFA, TG, WC, hip circumference, waist-to-height ratio, systolic blood pressure, pulse pressure index, and low-density lipoprotein cholesterol all positively correlated with CAS (  = 0.160 ~ 0.415,  = 0.000 ~ 0.032). After we controlled for traditional risk factors for cardiovascular disease, FFA levels remained positively correlated to the CAS (  = 0.365,