Insights into the Molecular Epidemiology of Foot-and-Mouth Disease Virus in Russia, Kazakhstan, and Mongolia in Terms of O/ME-SA/Ind-2001e Sublineage Expansion

Foot-and-mouth disease (FMD) has long been recognized as a highly contagious, transboundary disease of livestock incurring substantial losses and burdens to animal production and trade across Africa, the Middle East, and Asia. Due to the recent emergence of the O/ME-SA/Ind-2001 lineage globally cont...

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Bibliographic Details
Published in:Viruses 2023-02, Vol.15 (3), p.598
Main Authors: Nikiforov, Viktor, Shcherbakov, Alexey, Chvala, Ilya, Kremenchugskaya, Svetlana, Korennoy, Fedor, Mayorova, Tamara, Timina, Anna, Tyulegenov, Samat, Abdrakhmanov, Sarsenbay, Berdikulov, Maksat, Sainnokhoi, Tserenchimed, Gombo-Ochir, Delgerzul, Tserenchimed, Tsagaan, Prokhvatilova, Larisa, Sprygin, Alexander
Format: Article
Language:English
Subjects:
Analysis
Animals
Cattle
Epidemics
Epidemiology
evolution
Foot & mouth disease
Foot-and-Mouth Disease
Foot-and-Mouth Disease Virus
Genetic aspects
Genomes
Immunization
Kazakhstan - epidemiology
Laboratories
Livestock
Methods
Molecular Epidemiology
Mongolia - epidemiology
Mortality
Phylogeny
Proteins
Quarantine
Regions
Russia - epidemiology
Serogroup
Strains (organisms)
Surveillance
Vaccines
Viruses
VP1
VP1 protein
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Summary:Foot-and-mouth disease (FMD) has long been recognized as a highly contagious, transboundary disease of livestock incurring substantial losses and burdens to animal production and trade across Africa, the Middle East, and Asia. Due to the recent emergence of the O/ME-SA/Ind-2001 lineage globally contributing to the expansion of FMD, molecular epidemiological investigations help in tracing the evolution of foot-and-mouth disease virus (FMDV) across endemic and newly affected regions. In this work, our phylogenetic analysis reveals that the recent FMDV incursions in Russia, Mongolia, and Kazakhstan in 2021-2022 were due to the virus belonging to the O/ME-SA/Ind-2001e sublineage, belonging to the cluster from Cambodian FMDV isolates. The studied isolates varied by 1.0-4.0% at the VP1 nucleotide level. Vaccine matching tests indicated that the vaccination policy in the subregion should be tailored according to the peculiarities of the ongoing epidemiologic situation. The current vaccination should change from such vaccine strains as O Manisa (ME-SA), O no 2102/Zabaikalsky/2010 (O/ME-SA/Mya-98) (r = 0.05-0.28) to strains that most closely antigenically match the dominant lineage O No. 2212/Primorsky/2014 (O O/ME-SA//Mya-98) and O No. 2311/Zabaikalsky/2016 (O ME-SA/Ind-2001) (r = 0.66-1.0).
ISSN:1999-4915
1999-4915
DOI:10.3390/v15030598