The Role of CYP3A in Health and Disease

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); alm...

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Bibliographic Details
Published in:Biomedicines 2022-10, Vol.10 (11), p.2686
Main Authors: Klyushova, Lyubov S, Perepechaeva, Maria L, Grishanova, Alevtina Y
Format: Article
Language:English
Subjects:
Adrenal glands
CYP3A
CYP3A endogenous substrates
CYP3A in pathology
CYP3A regulation
CYP3A7 protein
Cytochrome
Cytochrome P-450
Cytochrome P450
drug-metabolizing enzymes
Endometrium
Enzymes
Esophagus
Fatty acids
Genomes
Hormones
Isoforms
Kidneys
Liver
Lungs
Metabolism
Molecular weight
Pancreas
Physiological aspects
Placenta
Prostate
Protein expression
Proteins
Review
Small intestine
Xenobiotics
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Summary:CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); almost the only common characteristic of these compounds is lipophilicity and a relatively large molecular weight. CYP3A enzymes are widely expressed in human organs and tissues, and consequences of these enzymes' activities play a major role both in normal regulation of physiological levels of endogenous compounds and in various pathological conditions. This review addresses these aspects of regulation of CYP3A enzymes under physiological conditions and their involvement in the initiation and progression of diseases.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10112686