Epigenetics in the pathogenesis of diabetic nephropathy

Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients. With further study on DN, it is found that epigenetics plays a crucial role in the pathophysiological process of DN. Epigenetics has an imp...

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Bibliographic Details
Published in:Acta biochimica et biophysica Sinica 2022-01, Vol.54 (2), p.163-172
Main Authors: Li, Xue, Lu, Lihong, Hou, Wenting, Huang, Ting, Chen, Xiangyuan, Qi, Jie, Zhao, Yanjun, Zhu, Minmin
Format: Article
Language:English
Subjects:
diabetes
Diabetes Mellitus - metabolism
Diabetic Nephropathies - genetics
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - pathology
diabetic nephropathy
Epigenesis, Genetic
epigenetics
Epigenomics
Histones - genetics
Histones - metabolism
Humans
Kidney - metabolism
metabolic memory
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Summary:Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients. With further study on DN, it is found that epigenetics plays a crucial role in the pathophysiological process of DN. Epigenetics has an important impact on the development of DN through a variety of mechanisms, and promotes the generation and maintenance of metabolic memory, thus ultimately leading to a poor prognosis. In this review we discuss the methylation of DNA, modification of histone, and regulation of non-coding RNA involved in the progress of cell dysfunction, inflammation and fibrosis in the kidney, which ultimately lead to the deterioration of DN.
ISSN:1672-9145
1745-7270
DOI:10.3724/abbs.2021016