Chronic Obstructive Pulmonary Disease and Incidence of Hip Fracture: A Nested Case-Control Study in the EpiChron Cohort

• Published in: International journal of chronic obstructive pulmonary disease 2020-01, Vol.15, p.2799-2806
• Main Authors: Díez-Manglano, Jesús, Berges Vidal, María, Martínez Barredo, Lucía, Poblador-Plou, Beatriz, Gimeno-Miguel, Antonio, Martínez Heras, Pilar, Prados-Torres, Alexandra
• Format: Article
• Language: English
• Subjects: Age; Aged; Airway management; Analysis; Arthritis; Benzodiazepines; Case-Control Studies; case-control study; Chronic illnesses; Chronic obstructive pulmonary disease; Comorbidity; Electronic health records; Female; Fractures; Heart failure; hip fracture; Hip Fractures - diagnosis; Hip Fractures - epidemiology; Hospitalization; Hospitals; Humans; Hypertension; Incidence; Liver diseases; Lung diseases, Obstructive; Male; Medical research; Medicine, Experimental; Mortality; Multivariate analysis; Obesity; Original Research; Osteoporosis; Patients; Population; Primary care; Public health; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - epidemiology; Respiratory agents; Risk Factors; Spain - epidemiology; Steroids; Stroke
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S270713

To determine whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture and identify other factors associated with hip fracture. Observational nested case-control study was conducted in Aragon, Spain in 2010. We included COPD patients aged >40 years, in the EpiChron cohort. Each COPD patient was matched for age, sex, and number of comorbidities with a control subject without COPD. Patients with an existing diagnosis of osteoporosis and those with hip fracture before 2011 were excluded. We collected baseline demographic, comorbidity, and pharmacological treatment data. During a 5-year follow-up period, we recorded the incidence of hip fracture. A logistic regression model was constructed to identify factors associated with hip fracture. The study population consisted of 26,517 COPD patients and the same number of controls (median [interquartile range] age, 74 [17] years; women, 24.7%). Smoking and heart failure were more frequent in COPD patients, and obesity, hypertension, diabetes, dyslipidemia, stroke, arthritis, and visual or hearing impairment were less frequent (all p