Urine biomarkers in ESSIC type 2 interstitial cystitis/bladder pain syndrome and overactive bladder with developing a novel diagnostic algorithm

This study aimed to investigate the diagnostic values of urine cytokines in interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB) patients, and to develop a novel diagnostic algorithm. Urine samples were collected from 40 IC/BPS, 40 OAB patients, and 30 controls. Commerci...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.914-914, Article 914
Main Authors: Jiang, Yuan-Hong, Jhang, Jia-Fong, Hsu, Yung-Hsiang, Ho, Han-Chen, Wu, Ya-Hui, Kuo, Hann-Chorng
Format: Article
Language:English
Subjects:
631/45
692/4025
Algorithms
Biomarkers
Bladder
CXCL10 protein
Cystitis
Cytokines
Eotaxin
Humanities and Social Sciences
Immunoassays
Interleukin 1 receptor antagonist
Interleukin 1 receptors
Interleukin 10
Interleukin 12
Interleukin 6
Monocyte chemoattractant protein 1
multidisciplinary
Nerve growth factor
Pain
Pharmacists
RANTES
Science
Science (multidisciplinary)
Urine
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Summary:This study aimed to investigate the diagnostic values of urine cytokines in interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB) patients, and to develop a novel diagnostic algorithm. Urine samples were collected from 40 IC/BPS, 40 OAB patients, and 30 controls. Commercially available multiplex immunoassays were used to analyze 31 targeted cytokines. Urine cytokine profiles were significantly different among study groups and controls. MIP-1β showed the highest sensitivity (92.2%) for identifying diseased study patients from controls. The cytokines with high diagnostic values for distinguishing between IC and OAB included IL-10, RANTES, eotaxin, CXCL10, IL-12p70, NGF, IL-6, IL-17A, MCP-1, and IL-1RA. The diagnostic algorithm was subsequently developed according to the diagnostic values obtained. MIP-1β was selected for the initial screening test to diagnose diseased patients and controls with diagnostic rates of 81.6% and 68.4%, respectively. As confirmation tests for IC/BPS, the diagnostic rates of eotaxin, CXCL10, and RANTES were 73.3%, 72.7%, and 69.7%, respectively. As the confirmation test for OAB, the diagnostic rate of IL-10 was 60%. Urine cytokine profiles of IC/BPS and OAB patients differed from those of controls and might be useful as biomarkers for diagnosis. A novel pilot diagnostic algorithm was developed based on these profiles.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-80131-5