The effect of ellagic acid on the metabolic syndrome: A review article

• Published in: Heliyon 2023-11, Vol.9 (11), p.e21844-e21844, Article e21844
• Main Authors: Naraki, Karim, Ghasemzadeh Rahbardar, Mahboobeh, Ajiboye, Basiru Olaitan, Hosseinzadeh, Hossein
• Format: Article
• Language: English
• Subjects: acetylcholine; biomedical research; blood; chemoprevention; cholesterol; diabetes; ellagic acid; Glucose; glucose transporters; high density lipoprotein; Hyperglycemia; hyperlipidemia; Hyperlipidemias; hypertension; Hypoglycemic agents; insulin receptor substrate proteins; insulin secretion; Insulins; interleukin-6; Interleukins; Lipoproteins; low density lipoprotein; malondialdehyde; metabolic syndrome; mitochondria; nitrates; nitrites; nitroprusside; obesity; Oxidative stress; reactive oxygen species; triacylglycerols; tumor necrosis factor-alpha
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2023.e21844

(s): Metabolic syndrome is a collection of metabolic abnormalities that includes hyperglycemia, dyslipidemia, hypertension, and obesity. Ellagic acid is found in various fruits and vegetables. It has been reported to have several pharmacological properties, such as antibacterial, antifungal, antiviral, anti-inflammatory, hepatoprotective, cardioprotective, chemopreventive, neuroprotective, gastroprotective, and antidiabetic. Our current study aims to shed light on the probable efficiency of ellagic acid in managing metabolic syndrome and its complications. To prepare the present review, the databases or search engines utilized included Scopus, PubMed, Science Direct, and Google Scholar, and relevant articles have been gathered with no time limit until March 2023. Several investigations indicated that ellagic acid could be a potent compound for the treatment of many disorders such as diabetes, hypertension, and hyperlipidemia by various mechanisms, including increasing insulin secretion, insulin receptor substrate protein 1 expression, regulating glucose transporter 4, triglyceride, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), attenuating tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), reactive oxygen species (ROS), malondialdehyde (MDA), and oxidative stress in related tissues. Furthermore, ellagic acid ameliorates mitochondrial function, upregulates uncoupling protein 1 (found in brown and white adipose tissues), and regulates blood levels of nitrate/nitrite and vascular relaxations in response to acetylcholine and sodium nitroprusside. Ellagic acid can treat or manage metabolic syndrome and associated complications, according to earlier studies. To validate the beneficial effects of ellagic acid on metabolic syndrome, additional preclinical and clinical research is necessary.