Risk factors for liver dysfunction and their clinical importance after gastric cancer surgery

Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with gastric cancer (GC). This study aimed to identify the risk factors for postoperative liver dysfunction and their clinical impact after GC surgery. We retrospectively analyzed the data o...

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Bibliographic Details
Published in:Scientific reports 2024-04, Vol.14 (1), p.8076-8076, Article 8076
Main Authors: Sumiyoshi, Shutaro, Kubota, Takeshi, Ohashi, Takuma, Nishibeppu, Keiji, Kiuchi, Jun, Shimizu, Hiroki, Arita, Tomohiro, Yamamoto, Yusuke, Konishi, Hirotaka, Morimura, Ryo, Kuriu, Yoshiaki, Shiozaki, Atsushi, Ikoma, Hisashi, Fujiwara, Hitoshi, Otsuji, Eigo
Format: Article
Language:English
Subjects:
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Clinical Relevance
Complications
Gastrectomy - adverse effects
Gastric cancer
Guanylate cyclase
Humanities and Social Sciences
Humans
Laparoscopy
Laparoscopy - adverse effects
Liver
Liver diseases
multidisciplinary
Patients
Postoperative
Postoperative Complications - etiology
Postoperative Complications - surgery
Retrospective Studies
Risk Factors
Robotic surgery
Science
Science (multidisciplinary)
Stomach Neoplasms - etiology
Survival
Terminology
Treatment Outcome
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Description
Summary:Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with gastric cancer (GC). This study aimed to identify the risk factors for postoperative liver dysfunction and their clinical impact after GC surgery. We retrospectively analyzed the data of 124 patients with GC who underwent laparoscopic or robotic surgery at Kyoto Prefectural University of Medicine between 2017 and 2019. Twenty (16.1%) patients with GC developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 ≥ Grade 3). Univariate analyses identified robotic surgery as a risk factor for postoperative liver dysfunction ( P  = 0.005). There was no correlation between the postoperative liver dysfunction status and postoperative complications or postoperative hospital stays. Patients with postoperative liver dysfunction did not have significantly worse overall survival ( P  = 0.296) or recurrence-free survival ( P  = 0.565) than those without postoperative liver dysfunction. Robotic surgery is a risk factor for postoperative liver dysfunction; however, postoperative liver dysfunction does not affect short or long-term outcomes.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-58644-0