Characteristics, Classification, and Application of Stem Cells Derived from Human Teeth

Since mesenchymal stem cells derived from human teeth are characterized as having the properties of excellent proliferation, multilineage differentiation, and immune regulation. Dental stem cells exhibit fibroblast-like microscopic appearance and express mesenchymal markers, embryonic markers, and v...

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Bibliographic Details
Published in:Stem cells international 2021-05, Vol.2021, p.1-11
Main Authors: Lei, Tong, Zhang, Xiaoshuang, Du, Hongwu
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antigens
Biomarkers
Bone healing
Bone marrow
Cancer
Cell adhesion & migration
Cell differentiation
Cell proliferation
Cell therapy
Dental materials
Dental pulp
Dentistry
Diabetes
Differentiation
Embryos
Fibroblasts
Health aspects
Hematopoietic stem cells
Heterogeneity
Immunoregulation
Mesenchyme
Nervous system diseases
Neurological diseases
Review
Stem cell research
Stem cells
Surface markers
Teeth
Tissue engineering
Type 2 diabetes
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Summary:Since mesenchymal stem cells derived from human teeth are characterized as having the properties of excellent proliferation, multilineage differentiation, and immune regulation. Dental stem cells exhibit fibroblast-like microscopic appearance and express mesenchymal markers, embryonic markers, and vascular markers but do not express hematopoietic markers. Dental stem cells are a mixed population with different sensitive markers, characteristics, and therapeutic effects. Single or combined surface markers are not only helpful for understanding the subpopulation of mixed stem cell populations according to cell function but also for improving the stable treatment effect of dental stem cells. Focusing on the discovery and characterization of stem cells isolated from human teeth over the past 20 years, this review outlines the effect of marker sorting on cell proliferation and differentiation ability and the assessment of the clinical application potential. Classified dental stem cells from markers and functional molecules can solve the problem of heterogeneity and ensure the efficacy of cell therapy strategies including dentistry, neurologic diseases, bone repair, and tissue engineering.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2021/8886854