Involvement of Vasoactive Intestinal Peptide Family Members in Diabetic Keratopathy

Diabetic keratopathy (DK) is a common ocular complication of diabetes, characterized by alteration of the normal wound-healing mechanism, reduction of epithelial hemidesmosomes, disruption of the basement membrane, impaired barrier function, reduced corneal sensitivity, corneal ulcers, and corneal e...

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Bibliographic Details
Published in:Applied sciences 2024-02, Vol.14 (5), p.1754
Main Authors: Maugeri, Grazia, D’Amico, Agata Grazia, Magrì, Benedetta, D’Agata, Velia
Format: Article
Language:English
Subjects:
ADNP
Cell cycle
Collagen
Cornea
Diabetes
diabetic keratopathy
Endothelium
Extracellular matrix
Genetic aspects
Glucose
Growth factors
Health aspects
Hyperglycemia
Insulin
Kinases
Lubricants & lubrication
Medical research
Medicine, Experimental
Morphology
Neuropeptides
Oxidative stress
PACAP
Peptides
Physiological aspects
Proteins
Tomography
Type 2 diabetes
Vasoactive intestinal peptides
VIP
Wound healing
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Summary:Diabetic keratopathy (DK) is a common ocular complication of diabetes, characterized by alteration of the normal wound-healing mechanism, reduction of epithelial hemidesmosomes, disruption of the basement membrane, impaired barrier function, reduced corneal sensitivity, corneal ulcers, and corneal edema. The limited number of clinical studies do not allow a full characterization of the pathophysiology of DK and, until now, effective therapeutic approaches have not been available. However, in recent years, neuropeptides gained great attention for their biochemical characteristics and therapeutic potential. This review focuses on the role of neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the eye and, in particular, in the cornea, in physiological conditions, or during DK, by providing an overview of this diabetes mellitus complication.
ISSN:2076-3417
2076-3417
DOI:10.3390/app14051754