Involvement of Vasoactive Intestinal Peptide Family Members in Diabetic Keratopathy

Diabetic keratopathy (DK) is a common ocular complication of diabetes, characterized by alteration of the normal wound-healing mechanism, reduction of epithelial hemidesmosomes, disruption of the basement membrane, impaired barrier function, reduced corneal sensitivity, corneal ulcers, and corneal e...

Full description

Saved in:
Bibliographic Details
Published in:Applied sciences 2024-02, Vol.14 (5), p.1754
Main Authors: Maugeri, Grazia, D’Amico, Agata Grazia, Magrì, Benedetta, D’Agata, Velia
Format: Article
Language:English
Subjects:
ADNP
Cell cycle
Collagen
Cornea
Diabetes
diabetic keratopathy
Endothelium
Extracellular matrix
Genetic aspects
Glucose
Growth factors
Health aspects
Hyperglycemia
Insulin
Kinases
Lubricants & lubrication
Medical research
Medicine, Experimental
Morphology
Neuropeptides
Oxidative stress
PACAP
Peptides
Physiological aspects
Proteins
Tomography
Type 2 diabetes
Vasoactive intestinal peptides
VIP
Wound healing
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c389t-eb58e4103e2d690a2972e6122ec7caab121360d39f1cf426279d8cfe62d4daee3
container_end_page
container_issue 5
container_start_page 1754
container_title Applied sciences
container_volume 14
creator Maugeri, Grazia
D’Amico, Agata Grazia
Magrì, Benedetta
D’Agata, Velia
description Diabetic keratopathy (DK) is a common ocular complication of diabetes, characterized by alteration of the normal wound-healing mechanism, reduction of epithelial hemidesmosomes, disruption of the basement membrane, impaired barrier function, reduced corneal sensitivity, corneal ulcers, and corneal edema. The limited number of clinical studies do not allow a full characterization of the pathophysiology of DK and, until now, effective therapeutic approaches have not been available. However, in recent years, neuropeptides gained great attention for their biochemical characteristics and therapeutic potential. This review focuses on the role of neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the eye and, in particular, in the cornea, in physiological conditions, or during DK, by providing an overview of this diabetes mellitus complication.
doi_str_mv 10.3390/app14051754
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7fbbf33a00c34943a7280c9918ac45d7</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A786422989</galeid><doaj_id>oai_doaj_org_article_7fbbf33a00c34943a7280c9918ac45d7</doaj_id><sourcerecordid>A786422989</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-eb58e4103e2d690a2972e6122ec7caab121360d39f1cf426279d8cfe62d4daee3</originalsourceid><addsrcrecordid>eNptUV1rFTEQXUTB0vbJPxDwUW7N126Sx1JtvbSi4MdrmE0mNZfdzZqkF-6_N3pFKzjzMMPhnMMcputeMHohhKGvYV2ZpD1TvXzSnXCqho2QTD19tD_vzkvZ0VaGCc3oSfdpu-zTtMcZl0pSIF-hJHA17pFsl4qlxgUm8hHXGj2Sa5jjdCDvcR4xFxIX8ibCiDU6cosZalqhfjucdc8CTAXPf8_T7sv1289X7zZ3H262V5d3Gye0qRsce42SUYHcD4YCN4rjwDhHpxzAyDgTA_XCBOaC5ANXxmsXcOBeekAUp9326OsT7Oya4wz5YBNE-wtI-d5CbrdNaFUYxyAEUOqENFKA4po6Y5gGJ3uvmtfLo9ea0_eHltvu0kNu2Yvlpu_lQKnSf1n30EzjElLN4OZYnL1UepCcG20a6-I_rNYe5-jSgiE2_B_Bq6PA5VRKxvAnDKP252_to9-KH0p8lKo</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2955460078</pqid></control><display><type>article</type><title>Involvement of Vasoactive Intestinal Peptide Family Members in Diabetic Keratopathy</title><source>Publicly Available Content Database</source><creator>Maugeri, Grazia ; D’Amico, Agata Grazia ; Magrì, Benedetta ; D’Agata, Velia</creator><creatorcontrib>Maugeri, Grazia ; D’Amico, Agata Grazia ; Magrì, Benedetta ; D’Agata, Velia</creatorcontrib><description>Diabetic keratopathy (DK) is a common ocular complication of diabetes, characterized by alteration of the normal wound-healing mechanism, reduction of epithelial hemidesmosomes, disruption of the basement membrane, impaired barrier function, reduced corneal sensitivity, corneal ulcers, and corneal edema. The limited number of clinical studies do not allow a full characterization of the pathophysiology of DK and, until now, effective therapeutic approaches have not been available. However, in recent years, neuropeptides gained great attention for their biochemical characteristics and therapeutic potential. This review focuses on the role of neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the eye and, in particular, in the cornea, in physiological conditions, or during DK, by providing an overview of this diabetes mellitus complication.</description><identifier>ISSN: 2076-3417</identifier><identifier>EISSN: 2076-3417</identifier><identifier>DOI: 10.3390/app14051754</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>ADNP ; Cell cycle ; Collagen ; Cornea ; Diabetes ; diabetic keratopathy ; Endothelium ; Extracellular matrix ; Genetic aspects ; Glucose ; Growth factors ; Health aspects ; Hyperglycemia ; Insulin ; Kinases ; Lubricants &amp; lubrication ; Medical research ; Medicine, Experimental ; Morphology ; Neuropeptides ; Oxidative stress ; PACAP ; Peptides ; Physiological aspects ; Proteins ; Tomography ; Type 2 diabetes ; Vasoactive intestinal peptides ; VIP ; Wound healing</subject><ispartof>Applied sciences, 2024-02, Vol.14 (5), p.1754</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c389t-eb58e4103e2d690a2972e6122ec7caab121360d39f1cf426279d8cfe62d4daee3</cites><orcidid>0000-0003-0173-4885 ; 0000-0003-1114-8265 ; 0000-0001-5316-0735</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2955460078/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2955460078?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590,75126</link.rule.ids></links><search><creatorcontrib>Maugeri, Grazia</creatorcontrib><creatorcontrib>D’Amico, Agata Grazia</creatorcontrib><creatorcontrib>Magrì, Benedetta</creatorcontrib><creatorcontrib>D’Agata, Velia</creatorcontrib><title>Involvement of Vasoactive Intestinal Peptide Family Members in Diabetic Keratopathy</title><title>Applied sciences</title><description>Diabetic keratopathy (DK) is a common ocular complication of diabetes, characterized by alteration of the normal wound-healing mechanism, reduction of epithelial hemidesmosomes, disruption of the basement membrane, impaired barrier function, reduced corneal sensitivity, corneal ulcers, and corneal edema. The limited number of clinical studies do not allow a full characterization of the pathophysiology of DK and, until now, effective therapeutic approaches have not been available. However, in recent years, neuropeptides gained great attention for their biochemical characteristics and therapeutic potential. This review focuses on the role of neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the eye and, in particular, in the cornea, in physiological conditions, or during DK, by providing an overview of this diabetes mellitus complication.</description><subject>ADNP</subject><subject>Cell cycle</subject><subject>Collagen</subject><subject>Cornea</subject><subject>Diabetes</subject><subject>diabetic keratopathy</subject><subject>Endothelium</subject><subject>Extracellular matrix</subject><subject>Genetic aspects</subject><subject>Glucose</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Kinases</subject><subject>Lubricants &amp; lubrication</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Morphology</subject><subject>Neuropeptides</subject><subject>Oxidative stress</subject><subject>PACAP</subject><subject>Peptides</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Tomography</subject><subject>Type 2 diabetes</subject><subject>Vasoactive intestinal peptides</subject><subject>VIP</subject><subject>Wound healing</subject><issn>2076-3417</issn><issn>2076-3417</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUV1rFTEQXUTB0vbJPxDwUW7N126Sx1JtvbSi4MdrmE0mNZfdzZqkF-6_N3pFKzjzMMPhnMMcputeMHohhKGvYV2ZpD1TvXzSnXCqho2QTD19tD_vzkvZ0VaGCc3oSfdpu-zTtMcZl0pSIF-hJHA17pFsl4qlxgUm8hHXGj2Sa5jjdCDvcR4xFxIX8ibCiDU6cosZalqhfjucdc8CTAXPf8_T7sv1289X7zZ3H262V5d3Gye0qRsce42SUYHcD4YCN4rjwDhHpxzAyDgTA_XCBOaC5ANXxmsXcOBeekAUp9326OsT7Oya4wz5YBNE-wtI-d5CbrdNaFUYxyAEUOqENFKA4po6Y5gGJ3uvmtfLo9ea0_eHltvu0kNu2Yvlpu_lQKnSf1n30EzjElLN4OZYnL1UepCcG20a6-I_rNYe5-jSgiE2_B_Bq6PA5VRKxvAnDKP252_to9-KH0p8lKo</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Maugeri, Grazia</creator><creator>D’Amico, Agata Grazia</creator><creator>Magrì, Benedetta</creator><creator>D’Agata, Velia</creator><general>MDPI AG</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0173-4885</orcidid><orcidid>https://orcid.org/0000-0003-1114-8265</orcidid><orcidid>https://orcid.org/0000-0001-5316-0735</orcidid></search><sort><creationdate>20240201</creationdate><title>Involvement of Vasoactive Intestinal Peptide Family Members in Diabetic Keratopathy</title><author>Maugeri, Grazia ; D’Amico, Agata Grazia ; Magrì, Benedetta ; D’Agata, Velia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-eb58e4103e2d690a2972e6122ec7caab121360d39f1cf426279d8cfe62d4daee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>ADNP</topic><topic>Cell cycle</topic><topic>Collagen</topic><topic>Cornea</topic><topic>Diabetes</topic><topic>diabetic keratopathy</topic><topic>Endothelium</topic><topic>Extracellular matrix</topic><topic>Genetic aspects</topic><topic>Glucose</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Kinases</topic><topic>Lubricants &amp; lubrication</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Morphology</topic><topic>Neuropeptides</topic><topic>Oxidative stress</topic><topic>PACAP</topic><topic>Peptides</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Tomography</topic><topic>Type 2 diabetes</topic><topic>Vasoactive intestinal peptides</topic><topic>VIP</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maugeri, Grazia</creatorcontrib><creatorcontrib>D’Amico, Agata Grazia</creatorcontrib><creatorcontrib>Magrì, Benedetta</creatorcontrib><creatorcontrib>D’Agata, Velia</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Applied sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maugeri, Grazia</au><au>D’Amico, Agata Grazia</au><au>Magrì, Benedetta</au><au>D’Agata, Velia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of Vasoactive Intestinal Peptide Family Members in Diabetic Keratopathy</atitle><jtitle>Applied sciences</jtitle><date>2024-02-01</date><risdate>2024</risdate><volume>14</volume><issue>5</issue><spage>1754</spage><pages>1754-</pages><issn>2076-3417</issn><eissn>2076-3417</eissn><abstract>Diabetic keratopathy (DK) is a common ocular complication of diabetes, characterized by alteration of the normal wound-healing mechanism, reduction of epithelial hemidesmosomes, disruption of the basement membrane, impaired barrier function, reduced corneal sensitivity, corneal ulcers, and corneal edema. The limited number of clinical studies do not allow a full characterization of the pathophysiology of DK and, until now, effective therapeutic approaches have not been available. However, in recent years, neuropeptides gained great attention for their biochemical characteristics and therapeutic potential. This review focuses on the role of neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the eye and, in particular, in the cornea, in physiological conditions, or during DK, by providing an overview of this diabetes mellitus complication.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/app14051754</doi><orcidid>https://orcid.org/0000-0003-0173-4885</orcidid><orcidid>https://orcid.org/0000-0003-1114-8265</orcidid><orcidid>https://orcid.org/0000-0001-5316-0735</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2076-3417
ispartof Applied sciences, 2024-02, Vol.14 (5), p.1754
issn 2076-3417
2076-3417
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_7fbbf33a00c34943a7280c9918ac45d7
source Publicly Available Content Database
subjects ADNP
Cell cycle
Collagen
Cornea
Diabetes
diabetic keratopathy
Endothelium
Extracellular matrix
Genetic aspects
Glucose
Growth factors
Health aspects
Hyperglycemia
Insulin
Kinases
Lubricants & lubrication
Medical research
Medicine, Experimental
Morphology
Neuropeptides
Oxidative stress
PACAP
Peptides
Physiological aspects
Proteins
Tomography
Type 2 diabetes
Vasoactive intestinal peptides
VIP
Wound healing
title Involvement of Vasoactive Intestinal Peptide Family Members in Diabetic Keratopathy
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A36%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Involvement%20of%20Vasoactive%20Intestinal%20Peptide%20Family%20Members%20in%20Diabetic%20Keratopathy&rft.jtitle=Applied%20sciences&rft.au=Maugeri,%20Grazia&rft.date=2024-02-01&rft.volume=14&rft.issue=5&rft.spage=1754&rft.pages=1754-&rft.issn=2076-3417&rft.eissn=2076-3417&rft_id=info:doi/10.3390/app14051754&rft_dat=%3Cgale_doaj_%3EA786422989%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c389t-eb58e4103e2d690a2972e6122ec7caab121360d39f1cf426279d8cfe62d4daee3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2955460078&rft_id=info:pmid/&rft_galeid=A786422989&rfr_iscdi=true