Structural and magnetic properties of cobalt-doped iron oxide nanoparticles prepared by solution combustion method for biomedical applications

• Published in: International journal of nanomedicine 2015-10, Vol.10 Suppl 1 (1), p.189-198
• Main Authors: Venkatesan, Kaliyamoorthy, Rajan Babu, Dhanakotti, Kavya Bai, Mane Prabhu, Supriya, Ravi, Vidya, Radhakrishnan, Madeswaran, Saminathan, Anandan, Pandurangan, Arivanandhan, Mukannan, Hayakawa, Yasuhiro
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Cell Proliferation - drug effects; Cobalt - chemistry; Ferric Compounds - chemistry; Humans; Magnetics; MCF-7 Cells; Microscopy, Electron, Transmission; Nanoparticles - chemistry; Original Research; Particle Size; Solutions; X-Ray Diffraction
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S82210

Cobalt-doped iron oxide nanoparticles were prepared by solution combustion technique. The structural and magnetic properties of the prepared samples were also investigated. The average crystallite size of cobalt ferrite (CoFe2O4) magnetic nanoparticle was calculated using Scherrer equation, and it was found to be 16±5 nm. The particle size was measured by transmission electron microscope. This value was found to match with the crystallite size calculated by Scherrer equation corresponding to the prominent intensity peak (311) of X-ray diffraction. The high-resolution transmission electron microscope image shows clear lattice fringes and high crystallinity of cobalt ferrite magnetic nanoparticles. The synthesized magnetic nanoparticles exhibited the saturation magnetization value of 47 emu/g and coercivity of 947 Oe. The anti-microbial activity of cobalt ferrite nanoparticles showed better results as an anti-bacterial agent. The affinity constant was determined for the nanoparticles, and the cytotoxicity studies were conducted for the cobalt ferrite nanoparticles at different concentrations and the results are discussed.