Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin ( Phyllostachys pubescens )

This study targets the evaluation of melanin synthesis inhibition activity of the bamboo shoot skin as agro-waste. The total methanolic extract of bamboo peel extract was evaluated for its skin protective effects via measuring its melanin inhibitory activity and its suppression activity on the expre...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.28 (1), p.23
Main Authors: Ashour, Ahmed, Elbermawi, Ahmed, Amen, Yhiya, Allam, Ahmed E, Ikeda, Hiromi, Nagata, Maki, Kumagae, Kenta, Azuma, Tomoyo, Taguchi, Aya, Takemoto, Takuya, Matsumoto, Masako, Shimizu, Kuniyoshi
Format: Article
Language:English
Subjects:
Aging
Aging (natural)
Agricultural wastes
agro-waste
Antioxidants
Bamboo
bamboo shoot skin
Betulinic acid
Biosynthesis
Chemical properties
Cognitive ability
Collagen
Dermatologic agents
Dermatology
Evaluation
Flavonoids
Formulae, receipts, prescriptions
Gene expression
Health aspects
Hyaluronic acid
Hyperpigmentation
Materia medica, Vegetable
Melanin
melanin inhibition
Melanoma
mRNA
Pharmaceutical research
Phyllostachys pubescens
Plant extracts
Proteins
Skin
Skin diseases
Triacontanol
Tyrosinase
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Summary:This study targets the evaluation of melanin synthesis inhibition activity of the bamboo shoot skin as agro-waste. The total methanolic extract of bamboo peel extract was evaluated for its skin protective effects via measuring its melanin inhibitory activity and its suppression activity on the expression of tyrosinase mRNA levels. Results showed that bamboo peel extract has a good ability for the inhibition of melanin synthesis so further studies were performed for the isolation of its constituents. Twelve compounds have been isolated from the shoot skin of . Their structures were elucidated based on extensive spectroscopic methods. The melanin inhibition potential of the isolates was tested with their collagen-production-promoting activity for the determination of active principles. Results showed that Betulinic acid, tachioside, and 1,2-dilinolenin significantly suppressed melanin production per cell compared to control. Triacontanol, tricin, and (+)-lyoniresinol 9'- -glucoside also tended to decrease melanin production per cell. These findings indicated that the skin of bamboo shoots, a significant agricultural waste, is a useful natural source for further research on its potential for aging problems such hyperpigmentation and cognitive function impairment.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28010023