Metabolomics of Cerebrospinal Fluid from Healthy Subjects Reveal Metabolites Associated with Ageing

To increase our understanding of age-related diseases affecting the central nervous system (CNS) it is important to understand the molecular processes of biological ageing. Metabolomics of cerebrospinal fluid (CSF) is a promising methodology to increase our understanding of naturally occurring proce...

Full description

Saved in:
Bibliographic Details
Published in:Metabolites 2021-02, Vol.11 (2), p.126
Main Authors: Carlsson, Henrik, Rollborn, Niclas, Herman, Stephanie, Freyhult, Eva, Svenningsson, Anders, Burman, Joachim, Kultima, Kim
Format: Article
Language:English
Subjects:
Age
ageing
Aging
Amino acids
Biomarkers
Brain
Central nervous system
Cerebrospinal fluid
Disease
Gender
high-resolution mass spectrometry
Isoleucine
Liquid chromatography
Mass spectroscopy
Medicin och hälsovetenskap
Metabolism
Metabolites
Metabolomics
Methionine
Plasma
Urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To increase our understanding of age-related diseases affecting the central nervous system (CNS) it is important to understand the molecular processes of biological ageing. Metabolomics of cerebrospinal fluid (CSF) is a promising methodology to increase our understanding of naturally occurring processes of ageing of the brain and CNS that could be reflected in CSF. In the present study the CSF metabolomes of healthy subjects aged 30-74 years ( = 23) were studied using liquid chromatography high-resolution mass spectrometry (LC-HRMS), and investigated in relation to age. Ten metabolites were identified with high confidence as significantly associated with ageing, eight with increasing levels with ageing: isoleucine, acetylcarnitine, pipecolate, methionine, glutarylcarnitine, 5-hydroxytryptophan, ketoleucine, and hippurate; and two decreasing with ageing: methylthioadenosine and 3-methyladenine. To our knowledge, this is the first time the CSF metabolomes of healthy subjects are assessed in relation to ageing. The present study contributes to the field of ageing metabolomics by presenting a number of metabolites present in CSF with potential relevance for ageing and the results motivate further studies.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo11020126