A new hydroxylated nonaprenylhydroquinone from the Mediterranean marine sponge Sarcotragus spinosulus

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and...

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Bibliographic Details
Published in:Marine drugs 2011-07, Vol.9 (7), p.1210-1219
Main Authors: Abed, Charline, Legrave, Nathalie, Dufies, Maeva, Robert, Guillaume, Guérineau, Vincent, Vacelet, Jean, Auberger, Patrick, Amade, Philippe, Mehiri, Mohamed
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
bioactivity
Cell Line, Tumor
Chemical Sciences
Drug Screening Assays, Antitumor
Humans
Hydroquinones - chemistry
Hydroquinones - isolation & purification
Hydroquinones - metabolism
Hydroquinones - pharmacology
hydroxylated polyprenylhydroquinone
Hydroxylation
Inhibitory Concentration 50
K562 Cells
marine natural products
Molecular Structure
Oceans and Seas
Organic chemistry
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - metabolism
Plant Extracts - pharmacology
ponges
Porifera - chemistry
Sarcotragus spinosulus
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Summary:Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.
ISSN:1660-3397
1660-3397
DOI:10.3390/md9071210