Ultrasound-assisted synthesis of dihydropyrimidine-2-thiones

Chalcone derivatives were prepared by the conden sation of various substituted aryl aldehydes and acetophenone in alkaline ethanol, while pyrimidine-2-thione derivatives were prepared by the combination of chalcones and thiourea under conventional and ultrasonic conditions. Advantages of the ultraso...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2011-01, Vol.76 (5), p.679-684
Main Authors: Safaei-Ghomi, J, Ghasemzadeh, MA
Format: Article
Language:English
Subjects:
chalcone derivatives
Condensing
Derivatives
Ethanol
Ethyl alcohol
Mathematical analysis
pyrimidine-2-thione derivatives
Spectra
Synthesis
Ultrasound
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Summary:Chalcone derivatives were prepared by the conden sation of various substituted aryl aldehydes and acetophenone in alkaline ethanol, while pyrimidine-2-thione derivatives were prepared by the combination of chalcones and thiourea under conventional and ultrasonic conditions. Advantages of the ultrasound effect were observed and high yields of the products were obtained after 20-30 min sonication. Characterization and structural elucidation of the products was realized based on chemical, analytical and spectral analyses. The results clearly demonstrated a high efficiency of the ultrasonic systems was achieved in the chemical processes.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC100212057S