Mechanism of Action of Dihydroquercetin in the Prevention and Therapy of Experimental Liver Injury

• Published in: Molecules (Basel, Switzerland) Switzerland), 2024-08, Vol.29 (15), p.3537
• Main Authors: Wei, Hewei, Zhao, Ting, Liu, Xinglong, Ding, Qiteng, Yang, Junran, Bi, Xiaoyu, Cheng, Zhiqiang, Ding, Chuanbo, Liu, Wencong
• Format: Article
• Language: English
• Subjects: Analgesics; Animals; Antioxidants - chemistry; Antioxidants - pharmacology; Antioxidants - therapeutic use; Bioflavonoids; biological availability; Carbon; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - prevention & control; Dehydrogenases; dihydroquercetin; Drug dosages; Enzymes; Flavones; Flavonoids; Health aspects; Hepatitis; Humans; Kinases; Liver - drug effects; Liver - injuries; Liver - metabolism; Liver - pathology; Liver diseases; Liver Diseases - drug therapy; Liver Diseases - metabolism; Liver Diseases - pathology; Liver Diseases - prevention & control; liver injury; mechanism; NF-kappa B - metabolism; Oxidative stress; Oxidative Stress - drug effects; Pazopanib; Quercetin - analogs & derivatives; Quercetin - chemistry; Quercetin - pharmacology; Quercetin - therapeutic use; Tumor necrosis factor; Type 2 diabetes; Well being; World health
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29153537

Liver disease is a global health problem that affects the well-being of tens of thousands of people. Dihydroquercetin (DHQ) is a flavonoid compound derived from various plants. Furthermore, DHQ has shown excellent activity in the prevention and treatment of liver injury, such as the inhibition of hepatocellular carcinoma cell proliferation after administration, the normalization of oxidative indices (like SOD, GSH) in this tissue, and the down-regulation of pro-inflammatory molecules (such as IL-6 and TNF-α). DHQ also exerts its therapeutic effects by affecting molecular pathways such as NF-κB and Nrf2. This paper discusses the latest research progress of DHQ in the treatment of various liver diseases (including viral liver injury, drug liver injury, alcoholic liver injury, non-alcoholic liver injury, fatty liver injury, and immune liver injury). It explores how to optimize the application of DHQ to improve its effectiveness in treating liver diseases, which is valuable for preparing potential therapeutic drugs for human liver diseases in conjunction with DHQ.