Phase-separated polymer blends for controlled drug delivery by tuning morphology

Controlling drug release rate and providing physical and chemical stability to the active pharmaceutical ingredient are key properties of oral solid dosage forms. Here, we demonstrate a formulation strategy using phase-separated polymer blends where the morphology provides a route for tuning the dru...

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Bibliographic Details
Published in:Communications materials 2024-10, Vol.5 (1), p.231-8, Article 231
Main Authors: Olsson, Martina, Storm, Robin, Björn, Linnea, Lilja, Viktor, Krupnik, Leonard, Chen, Yang, Naidjonoka, Polina, Diaz, Ana, Holler, Mirko, Watts, Benjamin, Larsson, Anette, Liebi, Marianne, Matic, Aleksandar
Format: Article
Language:English
Subjects:
639/301/923/1028
639/301/930/2735
692/308/153
Chemistry and Materials Science
Controlled release
Corrosion resistance
Dissolution
Dosage
Drug dosages
Formulations
Hydrophilicity
Materials Science
Morphology
Phase separation
Polymer blends
Polymers
Stability
Tomography
Tuning
X ray imagery
X ray microscopy
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Summary:Controlling drug release rate and providing physical and chemical stability to the active pharmaceutical ingredient are key properties of oral solid dosage forms. Here, we demonstrate a formulation strategy using phase-separated polymer blends where the morphology provides a route for tuning the drug release profile. By utilising phase separation of a hydrophobic and a hydrophilic polymer, the hydrophilic component will act as a channelling agent, creating a porous network upon dissolution that will dictate the release characteristics. With ptychographic X-ray tomography and scanning transmission X-ray microscopy we reveal how the morphology depends on both polymer fraction and presence of drug, and how the drug is distributed over the polymer domains. Combining X-ray imaging results with dissolution studies reveal how the morphologies are correlated with the drug release and showcase how tuning the morphology of a polymer matrix in oral formulations can be utilised as a method for controlled drug release. Drug delivery via solid oral dosage requires a controlled release rate and physical and chemical stability of the drug within the formulation. Here, X-ray tomography and spectromicroscopy reveal how the morphology of a phase-separated polymer blend controls drug release.
ISSN:2662-4443
2662-4443
DOI:10.1038/s43246-024-00678-y