POTENTIAL PREVENTIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS AND LACTOBACILLUS PLANTARUM IN PATIENTS WITH POLYPS OR COLORECTAL CÂNCER

Colorectal cancer is one of the major causes of death worldwide. Many studies have been done on the biology of its formation as well as its treatment in recent years. One of the factors involved in the formation or treatment of this malignancy can be attributed to the microbial flora in the intestin...

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Published in:Arquivos de gastroenterologia 2018-10, Vol.55 (4), p.407-411
Main Authors: Zinatizadeh, Nazi, Khalili, Farzad, Fallah, Parviz, Farid, Malihe, Geravand, Maryam, Yaslianifard, Somayeh
Format: Article
Language:English
Subjects:
Aged
Colonic Polyps - microbiology
Colonic Polyps - prevention & control
Colorectal neoplasms
Colorectal Neoplasms - microbiology
Colorectal Neoplasms - prevention & control
DNA, Bacterial - analysis
Feces - microbiology
Female
GASTROENTEROLOGY & HEPATOLOGY
Humans
Lactobacillus acidophilus - genetics
Lactobacillus acidophilus - isolation & purification
Lactobacillus acidophilus, Lactobacillus plantarum
Lactobacillus plantarum - genetics
Lactobacillus plantarum - isolation & purification
Male
Middle Aged
Polymerase Chain Reaction
Polyps
Probiotics
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Summary:Colorectal cancer is one of the major causes of death worldwide. Many studies have been done on the biology of its formation as well as its treatment in recent years. One of the factors involved in the formation or treatment of this malignancy can be attributed to the microbial flora in the intestine. This study investigate the potential preventive effect of Lactobacillus acidophilus and Lactobacillus plantarum in patients with polyps or colorectal cancer (CRC). A total of 77 samples were selected in the form of three groups including individuals suffering from CRC, polyps and healthy subjects. Genomic DNA of fecal specimens and standard strains were extracted and amplified employing primers targeting of the 16S rRNA gene for initial detection. Absolute Real Time PCR quantification was used to determine the copy of the bacterial expression per gram of feces. No significant difference were observed between age and gender in the mentioned groups (P=0.06). The average copy number of Lactobacillus acidophilus shows Significant difference between the healthy group and those with polyps (P
ISSN:0004-2803
1678-4219
1678-4219
DOI:10.1590/s0004-2803.201800000-87