Immunomodulatory activity of polysaccharide-protein complex of longan (Dimocarpus longan Lour.) pulp

The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg⁻¹d⁻¹ LP3 could significantly increase/enhance antibody production against chicken red blood cell (CR...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2011-12, Vol.16 (12), p.10324-10336
Main Authors: Yi, Yang, Liao, Sen-Tai, Zhang, Ming-Wei, Zhang, Rui-Fen, Deng, Yuan-Yuan, Yang, Bao, Wei, Zhen-Cheng
Format: Article
Language:English
Subjects:
Animals
Body Weight - drug effects
Cell Death - drug effects
Cell Proliferation - drug effects
Chemotherapy
Chickens
cyclophosphamide
Cytotoxicity
Drinking Behavior - drug effects
Feeding Behavior - drug effects
Glycoproteins - chemistry
Glycoproteins - pharmacology
Hemolysin Proteins - blood
Immunologic Factors - pharmacology
immunomodulatory activity
immunosuppressed mice
Interferon-gamma - blood
Interleukin-2 - blood
Killer Cells, Natural - cytology
Killer Cells, Natural - drug effects
longan pulp
Lymphocytes - cytology
Lymphocytes - drug effects
Lymphoma
Macrophages - cytology
Macrophages - drug effects
Male
Mice
Phagocytosis - drug effects
Plant Extracts - pharmacology
polysaccharide-protein complex
Polysaccharides - pharmacology
Proteins
Sapindaceae - chemistry
Spleen - cytology
Spleen - drug effects
Thymus Gland - drug effects
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Summary:The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg⁻¹d⁻¹ LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg⁻¹d⁻¹ LP3 (P < 0.05). The beneficial effects of 50-200 mgkg⁻¹d⁻¹ LP3 were comparable to those of 50 mgkg⁻¹d⁻¹ ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules161210324