Molecular profiling of primary endometrioid endometrial cancer and matched lung metastases: CTNNB1 mutation as a potential driver

•Both primary endometrial cancers (ECs) and matched lung metastases shared a common ancestor with independent evolution at each site.•The two endometrioid ECs studied acquired additional mutations during the distant metastatic process.•Subclonal CTNNB1 hotspot mutations in the two primary ECs studie...

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Bibliographic Details
Published in:Gynecologic oncology reports 2024-06, Vol.53, p.101391, Article 101391
Main Authors: Gordhandas, Sushmita, Da Cruz Paula, Arnaud, Kertowidjojo, Elizabeth C., Pareja, Fresia, Dessources, Kimberly, da Silva, Edaise M., Derakhshan, Fatemeh, Mueller, Jennifer J., Abu-Rustum, Nadeem R., Chui, M. Herman, Weigelt, Britta
Format: Article
Language:English
Subjects:
CTNNB1
Endometrial cancer
Lung metastasis
Mutational signatures
Survey
Whole-exome sequencing
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Summary:•Both primary endometrial cancers (ECs) and matched lung metastases shared a common ancestor with independent evolution at each site.•The two endometrioid ECs studied acquired additional mutations during the distant metastatic process.•Subclonal CTNNB1 hotspot mutations in the two primary ECs studied became clonal in the distant metastases.
ISSN:2352-5789
2352-5789
DOI:10.1016/j.gore.2024.101391