MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

Allograft rejection is a widespread complication in allograft recipients with chronic kidney disease. Undertreatment of subclinical and clinical rejection and later post-transplant problems are caused by an imperfect understanding of the mechanisms at play and a lack of adequate diagnostic tools. Ma...

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Bibliographic Details
Published in:Biomedicines 2024-01, Vol.12 (1), p.116
Main Authors: Legaz, Isabel, Jimenez-Coll, Víctor, González-López, Rosana, Fernández-González, Marina, Alegría-Marcos, María José, Galián, José Antonio, Botella, Carmen, Moya-Quiles, Rosa, Muro-Pérez, Manuel, Minguela, Alfredo, Llorente, Santiago, Muro, Manuel
Format: Article
Language:English
Subjects:
allograft rejection
Allografts
B cells
Bibliometrics
Biological markers
biomarker
Biomarkers
Cancer
Cell cycle
Cell death
chronic kidney disease
Chronic kidney failure
Development and progression
Disease
Epigenetic inheritance
Epigenetics
Gene expression
Graft rejection
Health aspects
Homeostasis
Immunological tolerance
Kidney diseases
Kidney transplantation
Metabolism
MicroRNA
MicroRNAs
miRNA
Proteins
RNA polymerase
Systematic review
tolerance
Transplantation of organs, tissues, etc
Transplants & implants
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Summary:Allograft rejection is a widespread complication in allograft recipients with chronic kidney disease. Undertreatment of subclinical and clinical rejection and later post-transplant problems are caused by an imperfect understanding of the mechanisms at play and a lack of adequate diagnostic tools. Many different biomarkers have been analyzed and proposed to detect and monitor these crucial events in transplant outcomes. In this sense, microRNAs may help diagnose rejection or tolerance and indicate appropriate treatment, especially in patients with chronic allograft rejection. As key epigenetic regulators of physiological homeostasis, microRNAs have therapeutic potential and may indicate allograft tolerance or rejection. However, more evidence and clinical validation are indispensable before microRNAs are ready for clinical prime time.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12010116