Understanding the Dynamics of Inflammatory Cytokines in Endodontic Diagnosis: A Systematic Review

The primary aim of this literature review is to delineate the key inflammatory cytokines involved in the pathophysiology of pulp inflammation. By elucidating the roles of these cytokines, a deeper comprehension of the distinct stages of inflamed pulp can be attained, thereby facilitating more accura...

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Bibliographic Details
Published in:Diagnostics (Basel) 2024-05, Vol.14 (11), p.1099
Main Authors: Barbero-Navarro, Ignacio, Irigoyen-Camacho, Maria Esther, Zepeda-Zepeda, Marco Antonio, Ribas-Perez, David, Castaño-Seiquer, Antonio, Sofian-Pauliuc, Iuliana
Format: Article
Language:English
Subjects:
B cells
Bacteria
Chemokines
Cytokines
Dental pulp
Diagnosis
endodontics
Immune system
Infections
Inflammation
Literature reviews
Medical prognosis
root canal debridement
root canal therapy
root canal treatment
Systematic Review
Tumor necrosis factor-TNF
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Summary:The primary aim of this literature review is to delineate the key inflammatory cytokines involved in the pathophysiology of pulp inflammation. By elucidating the roles of these cytokines, a deeper comprehension of the distinct stages of inflamed pulp can be attained, thereby facilitating more accurate diagnostic strategies in endodontics. The PRISMA statement and Cochrane handbook were used for the search strategy. The keywords were created based on the review question using the PICO framework. The relevant studies were meticulously assessed according to predefined inclusion and exclusion criteria for this systematic review. A rigorous quality checklist was implemented to evaluate each included study, ensuring scrutiny for both quality and risk-of-bias assessments. The initial pilot search conducted on PubMed, Scopus, Cochrane, and WoS databases yielded 9 pertinent articles. Within these articles, multiple cytokines were identified and discussed as potential candidates for use in endodontic diagnosis, notably including IL-8, IL-6, TNF-α, and IL-2. These cytokines have been highlighted due to their significant roles in the inflammatory processes associated with pulp pathology. The identification of specific inflammatory cytokines holds promise for enhancing endodontic diagnostic procedures and exploring diverse treatment modalities. However, the current body of research in this area remains limited. Further comprehensive studies are warranted to fully elucidate the potential of cytokines in refining diagnostic techniques in endodontics.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14111099