Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?

• Published in: Nutrients 2020-08, Vol.12 (9), p.2517
• Main Authors: Perichart-Perera, Otilia, González-Leyva, Carla Patricia, González-Ludlow, Isabel, Tolentino-Dolores, Maricruz, Solis-Paredes, Mario, Reyes-Muñoz, Enrique, Borboa-Olivares, Hector, Sánchez-Martínez, Maribel, Parra-Hernández, Sandra, Monterrubio-Flores, Eric, Schnaas Y Arrieta, Lourdes, Guzmán-Huerta, Mario, Estrada-Gutierrez, Guadalupe
• Format: Article
• Language: English
• Subjects: Autumn; Body mass; Body mass index; Body size; Body weight; Calciferol; Cholecalciferol - administration & dosage; Cohort Studies; Complications; Diabetes; Dietary Supplements; Drug dosages; Female; Gestational age; Health care; Humans; Hypertension; Maternal Nutritional Physiological Phenomena - physiology; Metabolism; Mexico - epidemiology; Nutrition; Nutritional Requirements; Obesity; Obesity, Maternal - metabolism; Overweight; Preeclampsia; Pregnancy; Pregnancy complications; Pregnancy Complications - diet therapy; Pregnancy Complications - epidemiology; Pregnancy Complications - prevention & control; Pregnant Women; Prenatal care; Prevalence; serum 25-OH-D; Statistical analysis; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - diet therapy; Vitamin D Deficiency - epidemiology; Vitamin D Deficiency - prevention & control; vitamin D status; Vitamin D3; Vitamin deficiency; Womens health
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12092517

Controversy remains surrounding vitamin D routine supplementation in healthy pregnancy, and the doses are unclear. The aim of this study was to describe maternal vitamin D status throughout pregnancy in a group of Mexican women and evaluate the effect of frequently prescribed doses of vitamin D3 on longitudinal 25-OH-D concentrations, adjusting for obesity, season, and other factors. We conducted a cohort study (Instituto Nacional de Perinatología-INPer) (2017-2020)) of healthy pregnant women without complications. Pregestational overweight/obesity (body mass index ≥ 25), vitamin D3 supplementation (prescribed by physician; 0-250, 250-400, and >400 IU/day), and serum 25-OH-D concentrations (ELISA) were evaluated in each trimester of pregnancy. Vitamin D deficiency or insufficiency was computed (400 IU/day. Common supplementation doses of 250-400 IU/day were insufficient for achieving an adequate maternal vitamin D status.