Usefulness of presepsin for the early detection of infectious complications after elective colorectal surgery, compared with C-reactive protein and procalcitonin

• Published in: Scientific reports 2022-03, Vol.12 (1), p.3960-3960, Article 3960
• Main Authors: Amanai, Erika, Nakai, Kishiko, Saito, Junichi, Hashiba, Eiji, Miura, Takuya, Morohashi, Hajime, Sakamoto, Yoshiyuki, Mikami, Akio, Hakamada, Kenichi, Hirota, Kazuyoshi
• Format: Article
• Language: English
• Subjects: 692/308; 692/53; Adult; Biomarkers; C-reactive protein; C-Reactive Protein - metabolism; Colorectal surgery; Colorectal Surgery - adverse effects; Communicable Diseases - etiology; Elective Surgical Procedures - adverse effects; Humanities and Social Sciences; Humans; Lipopolysaccharide Receptors - metabolism; Middle Aged; multidisciplinary; Observational studies; Patients; Peptide Fragments - metabolism; Plasma levels; Postoperative Complications - diagnosis; Postoperative Complications - etiology; Procalcitonin; Science; Science (multidisciplinary); Sepsis; Surgery; Trends
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-06613-w

Infectious complications remain a major clinical problem in colorectal surgery. Presepsin has been reported to be a useful marker to diagnose sepsis, similar or superior to procalcitonin (PCT) and C-reactive protein (CRP). The aim of this study was to assess the diagnostic value of presepsin in the early detection of infectious complications after elective colorectal surgery, compared with CRP and PCT. This study was a prospective observational study. Patients of age > 18 who underwent elective colon resections were enrolled. Blood samples were collected just before surgery and on postoperative day (POD) 1, 2, 3, 4, and 6 to measure plasma levels of biomarkers. We evaluated the association between circulating biomarkers and infections. A total of 114 patients were examined, and 27 patients (23.7%) developed infectious complications. CRP and PCT markedly increased from POD 1 to POD 3 and then gradually decreased toward POD 6 in both groups, but the trends of the decrease in the infected group were blunt, compared with those in the non-infected group. On the other hand, presepsin did not show major changes just after surgery, but it increased on POD 4 and POD 6, when the complications occurred. Monitoring the presepsin trends after colorectal surgeries could be helpful to detect postoperative infectious complications. Trial registration: UMIN000025313. Registered on 17 December 2016.