Regulatory roles of ACSL5 in the anti-tumor function of palmitic acid (C16:0) via the ERK signaling pathway

Previous studies have highlighted the susceptibility of cancer to perturbations in lipid metabolism. In particular, C16:0 has emerged as a promising novel treatment for hepatocellular carcinoma. In our study, we investigated the levels of C16:0 in the serum of non-small lung cancer patients were sig...

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Bibliographic Details
Published in:European journal of histochemistry 2023-11, Vol.67 (4)
Main Authors: Lv, Jiapei, Yanting, Wang, Wei, Shan
Format: Article
Language:English
Subjects:
Acyl-CoA synthase long chain family member 5
Animals
Apoptosis
Carcinoma, Non-Small-Cell Lung - genetics
Cell Line, Tumor
Cell Proliferation
Coenzyme A Ligases - metabolism
Coenzyme A Ligases - pharmacology
ERK signal pathway
Humans
Lung Neoplasms - genetics
Mice
Non-small lung cancer
palmitic acid (C16:0)
Palmitic Acid - pharmacology
Palmitic Acid - therapeutic use
Signal Transduction
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Summary:Previous studies have highlighted the susceptibility of cancer to perturbations in lipid metabolism. In particular, C16:0 has emerged as a promising novel treatment for hepatocellular carcinoma. In our study, we investigated the levels of C16:0 in the serum of non-small lung cancer patients were significant downregulation compared to healthy individuals (n=10; p
ISSN:1121-760X
2038-8306
DOI:10.4081/ejh.2023.3867