Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models

A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helica...

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Bibliographic Details
Published in:Scientific reports 2017-04, Vol.7 (1), p.1173-10, Article 1173
Main Authors: Koo, Youngmi, Tiasha, Tarannum, Shanov, Vesselin N., Yun, Yeoheung
Format: Article
Language:English
Subjects:
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631/61/54/993
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Animal models
Coronary vessels
Environmental degradation
Etching
Humanities and Social Sciences
Implants
Magnesium
Manufacturing
multidisciplinary
Residual stress
Science
Science (multidisciplinary)
Shear stress
Stents
Thrombosis
Veins & arteries
Viscosity
Yield stress
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Summary:A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helical stent was inserted and expanded in vessels with subsequent degradation in various environments including static, dynamic, and porcine ex vivo models. By assessing stent degradation in three different environments, we observed: (1) stress- and flow-induced degradation; (2) a high degradation rate in the dynamic reactor; (3) production of intermediate products (MgO/Mg(OH) 2 and Ca/P) during degradation; and (4) intermediate micro-gas pocket formation in the neighboring tissue ex vivo model. Overall, the expandable Mg-based helical stent employed as a scaffold performed well, with expansion rate (>100%) in porcine ex vivo model.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-01214-4