Relative Efficacy of Piracetam, Modafinil and Citicoline on Cognitive Function in an Animal Model

Introduction: Nootropic drugs or cognitive enhancers are pharmacological agents that improve cognitive function and memory by various mechanisms. Drugs like piracetam, modafinil and citicoline have been used as nootropic agents. Aim: To compare the relative efficacy of nootropics like piracetam, mod...

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Published in:Journal of clinical and diagnostic research 2017-11, Vol.11 (11), p.FC01-FC03
Main Authors: Ahmad, Farrukh, Nayak, Veena, Malalur, Chaitanya, Mathew, Rinz, Tripathy, Amruta, Bairy, Kurady Laxminarayana
Format: Article
Language:English
Subjects:
Dementia
Memory
Morris water maze
Nootropics
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Summary:Introduction: Nootropic drugs or cognitive enhancers are pharmacological agents that improve cognitive function and memory by various mechanisms. Drugs like piracetam, modafinil and citicoline have been used as nootropic agents. Aim: To compare the relative efficacy of nootropics like piracetam, modafinil and citicoline on learning and memory in rats using the Morris water maze test. Materials and Methods: A total of 30 Wistar rats were used for the study. The animals were divided into five groups (n=6). The groups I to V received gum acacia orally, scopolamine 2 mg/kg intraperitoneally, piracetam (52.5 mg/kg), modafinil (2.5 mg/kg), citicoline (25 mg/kg) respectively orally for twenty days. Learning and memory was evaluated using the Morris water maze test. The animals were trained in the Morris water maze on the last five days of dosing. Scopolamine 2 mg/kg was administered intraperitoneally to the above groups of animals (except Groups I and II) for induction of amnesia, 45 minutes before the behavioural test. Results: Scopolamine induced marked impairment of memory evidenced by significant reduction (p
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2017/27838.10816