The role of inflammation in silicosis

Silicosis is a chronic illness marked by diffuse fibrosis in lung tissue resulting from continuous exposure to SiO -rich dust in the workplace. The onset and progression of silicosis is a complicated and poorly understood pathological process involving numerous cells and molecules. However, silicosi...

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Bibliographic Details
Published in:Frontiers in pharmacology 2024-03, Vol.15, p.1362509-1362509
Main Authors: Liu, Tong-Tong, Sun, Hai-Fei, Han, Yan-Xing, Zhan, Yun, Jiang, Jian-Dong
Format: Article
Language:English
Subjects:
cytokines
immune cells
inflammation
Pharmacology
signal pathway
silicosis
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Summary:Silicosis is a chronic illness marked by diffuse fibrosis in lung tissue resulting from continuous exposure to SiO -rich dust in the workplace. The onset and progression of silicosis is a complicated and poorly understood pathological process involving numerous cells and molecules. However, silicosis poses a severe threat to public health in developing countries, where it is the most prevalent occupational disease. There is convincing evidence supporting that innate and adaptive immune cells, as well as their cytokines, play a significant role in the development of silicosis. In this review, we describe the roles of immune cells and cytokines in silicosis, and summarize current knowledge on several important inflammatory signaling pathways associated with the disease, aiming to provide novel targets and strategies for the treatment of silicosis-related inflammation.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2024.1362509