Sebocytes contribute to melasma onset

Melasma is a hyperpigmentary disorder with photoaging features, whose manifestations appear on specific face areas, rich in sebaceous glands (SGs). To explore the SGs possible contribution to the onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to...

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Published in:iScience 2022-03, Vol.25 (3), p.103871-103871, Article 103871
Main Authors: Flori, Enrica, Mastrofrancesco, Arianna, Mosca, Sarah, Ottaviani, Monica, Briganti, Stefania, Cardinali, Giorgia, Filoni, Angela, Cameli, Norma, Zaccarini, Marco, Zouboulis, Christos C., Picardo, Mauro
Format: Article
Language:English
Subjects:
Biochemistry
Biological sciences
Molecular biology
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Summary:Melasma is a hyperpigmentary disorder with photoaging features, whose manifestations appear on specific face areas, rich in sebaceous glands (SGs). To explore the SGs possible contribution to the onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to single or repetitive ultraviolet (UVA) radiation was evaluated. UVA up-modulated the long-lasting production of α-MSH, EDN1, b-FGF, SCF, inflammatory cytokines and mediators. Irradiated SZ95 sebocyte conditioned media increased pigmentation in melanocytes and the expression of senescence markers, pro-inflammatory cytokines, and growth factors regulating melanogenesis in fibroblasts cultures. Cocultures experiments with skin explants confirmed the role of sebocytes on melanogenesis promotion. The analysis on sebum collected from melasma patients demonstrated that in vivo sebocytes from lesional areas express the UVA-activated pathways markers observed in vitro. Our results indicate sebocytes as one of the actors in melasma pathogenesis, inducing prolonged skin cell stimulation, contributing to localized dermal aging and hyperpigmentation. [Display omitted] •Irradiated sebocytes produce and upregulate the factors α-MSH, EDN1, SCF. and b-FGF•Sebocyte-derived factors drive modifications of fibroblasts and melanocyte behavior•Sebocytes participate in the skin cells cross-talk regulating pigmentation•Sebocytes locally support the inflammatory and photo-aged environment in melasma Biological sciences; Biochemistry; Molecular biology
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2022.103871