Left Atrial Appendage Opacification on Cardiac Computed Tomography in Acute Ischemic Stroke: The Clinical Implications of Slow-Flow

• Published in: Journal of the American Heart Association 2024-09, Vol.13 (17), p.e034106
• Main Authors: Nio, Shan Sui, Rinkel, Leon A, Cramer, Olivia N, Özata, Z Beyda, Beemsterboer, Chiel F P, Guglielmi, Valeria, Bouma, Berto J, Boekholdt, S Matthijs, Lobé, Nick H J, Beenen, Ludo F M, Marquering, Henk A, Majoie, Charles B L M, Roos, Yvo B W E M, van Randen, Adrienne, Planken, R Nils, Coutinho, Jonathan M
• Format: Article
• Language: English
• Subjects: acute ischemic stroke; Aged; Aged, 80 and over; Atrial Appendage - diagnostic imaging; Atrial Appendage - physiopathology; Atrial Fibrillation - complications; Atrial Fibrillation - diagnostic imaging; Atrial Fibrillation - physiopathology; computed tomography angiography; Female; filling defect; Humans; Ischemic Stroke - diagnostic imaging; Ischemic Stroke - etiology; Ischemic Stroke - physiopathology; JAHA Spotlight: Neurocardiology; Male; Middle Aged; Original Research; Predictive Value of Tests; Prospective Studies; Recurrence; Risk Factors; slow‐flow; Thrombosis - diagnostic imaging; Thrombosis - etiology; Thrombosis - physiopathology; Time Factors; Tomography, X-Ray Computed
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.123.034106

Left atrial appendage (LAA) slow-flow may increase the risk of ischemic stroke. We studied LAA attenuation on cardiac computed tomography in patients with acute ischemic stroke. We used data from a prospective cohort of patients with acute ischemic stroke undergoing cardiac computed tomography during the acute stroke imaging protocol. We compared characteristics, functional outcome (modified Rankin scale: higher scores indicating worse outcome), stroke recurrence and major adverse cardiovascular events after 2-year follow-up between patients with LAA thrombus (filling defect