Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice

Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss. However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare. ADSCs exert biological functions via the paracrine actions of va...

Full description

Saved in:
Bibliographic Details
Published in:Stem cells international 2020, Vol.2020 (2020), p.1-11
Main Authors: Wei, Zairong, Wang, Dali, Liu, Zhiyuan, Mo, Xiaojin, Deng, Yurong, Xiao, Shune, Deng, Chengliang
Format: Article
Language:English
Subjects:
Alopecia
Baldness
Cell adhesion & migration
Cell proliferation
Cell therapy
Cytokines
Ethylenediaminetetraacetic acid
Extracellular matrix
Growth
Growth factors
Hair
Hair loss
Mice
Neovascularization
Paracrine signalling
Penicillin
Regeneration (physiology)
Regenerative medicine
Stem cell transplantation
Stem cells
Transplantation
Vascular endothelial growth factor
Vascularization
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss. However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare. ADSCs exert biological functions via the paracrine actions of various growth factors and cytokines. Conditioned medium from ADSCs (ADSCs-CM) is a cell-free suspension rich in growth factors and cytokines that has demonstrated a significant role in stimulating hair growth, with encouraging outcomes in terms of hair regeneration and hair growth. Extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) is an ADSC- and adipose native extracellular matrix-enriched product for cytotherapy. In this study, we compared the effects of CM from ECM/SVF-gel (ECM/SVF-CM) and from stem cells (SVF-CM) on hair growth in mice. ECM/SVF-CM stimulated hair growth more than SVF-CM, through promoting the proliferation of dermal papilla cells and cells in the bulge, neovascularization, and anagen induction. ECM/SVF-CM might, thus, provide an effective and improved strategy for promoting hair growth. These data provide a theoretical foundation for the clinical administration of ECM/SVF-CM for the treatment of hair loss.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2020/9054514