Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases

PDZ (postsynaptic density (PSD95), discs large (Dlg), and zonula occludens (ZO-1)-dependent interactions are widely distributed within different cell types and regulate a variety of cellular processes. To date, some of these interactions have been identified as targets of small molecules or peptides...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-10, Vol.26 (21), p.6367
Main Authors: Gutiérrez-González, Luis H, Rivas-Fuentes, Selma, Guzmán-Beltrán, Silvia, Flores-Flores, Angélica, Rosas-García, Jorge, Santos-Mendoza, Teresa
Format: Article
Language:English
Subjects:
Amino acids
Animals
Apoptosis
Cancer therapies
Central nervous system
Chemokines
Clinical trials
Disease Management
Disease Susceptibility
Homeostasis
Humans
Immune system
Immune System Diseases - drug therapy
Immune System Diseases - etiology
Immune System Diseases - metabolism
immune-related disorders
Kinases
Ligands
Models, Molecular
Molecular Targeted Therapy
Nitric oxide
Pathogens
PDZ domains
PDZ Domains - drug effects
PDZ-dependent interactions
peptide inhibitors
Peptides
Peptides - chemistry
Peptides - pharmacology
Peptides - therapeutic use
Pharmacology
Postsynaptic density
Postsynaptic density proteins
Protein Binding - drug effects
Protein Conformation
Protein interaction
Protein Interaction Domains and Motifs - drug effects
Proteins
Review
Signal transduction
Structure-Activity Relationship
Structure-function relationships
Viruses
Zonula occludens-1 protein
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Description
Summary:PDZ (postsynaptic density (PSD95), discs large (Dlg), and zonula occludens (ZO-1)-dependent interactions are widely distributed within different cell types and regulate a variety of cellular processes. To date, some of these interactions have been identified as targets of small molecules or peptides, mainly related to central nervous system disorders and cancer. Recently, the knowledge of PDZ proteins and their interactions has been extended to various cell types of the immune system, suggesting that their targeting by viral pathogens may constitute an immune evasion mechanism that favors viral replication and dissemination. Thus, the pharmacological modulation of these interactions, either with small molecules or peptides, could help in the control of some immune-related diseases. Deeper structural and functional knowledge of this kind of protein-protein interactions, especially in immune cells, will uncover novel pharmacological targets for a diversity of clinical conditions.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26216367