Arcobacter: an emerging food-borne zoonotic pathogen, its public health concerns and advances in diagnosis and control - a comprehensive review

• Published in: The Veterinary quarterly 2017-01, Vol.37 (1), p.136-161
• Main Authors: Ramees, Thadiyam Puram, Dhama, Kuldeep, Karthik, Kumaragurubaran, Rathore, Ramswaroop Singh, Kumar, Ashok, Saminathan, Mani, Tiwari, Ruchi, Malik, Yashpal Singh, Singh, Raj Kumar
• Format: Article
• Language: English
• Subjects: Animal diseases; Animals; Antibiotic resistance; Antibiotics; Arcobacter; Arcobacter - genetics; Arcobacter - pathogenicity; Bacteremia; Biochemical tests; Communicable Diseases, Emerging; control; Diagnosis; Diagnostic systems; Diarrhea; Domestic animals; Drug Resistance, Bacterial; emergence; Endocarditis; Epidemiology; Etiology; Evolution; Food; Food contamination; Food contamination & poisoning; Food sources; food-borne; Foodborne Diseases - diagnosis; Foodborne Diseases - epidemiology; Foodborne Diseases - microbiology; Foodborne Diseases - prevention & control; Gastroenteritis; Genetic diversity; Gram-Negative Bacterial Infections - diagnosis; Gram-Negative Bacterial Infections - epidemiology; Gram-Negative Bacterial Infections - genetics; Gram-Negative Bacterial Infections - prevention & control; Horses; Humans; Lizards; Mastitis; Meat; Pathogens; Peritonitis; Pork; Poultry; Public health; Reptiles; Sheep; Snakes; Species; Species diversity; Swine; Water pollution; Zoonoses; Zoonoses - epidemiology; zoonosis
• ISSN: 0165-2176; 1875-5941
• DOI: 10.1080/01652176.2017.1323355

Arcobacter has emerged as an important food-borne zoonotic pathogen, causing sometimes serious infections in humans and animals. Newer species of Arcobacter are being incessantly emerging (presently 25 species have been identified) with novel information on the evolutionary mechanisms and genetic diversity among different Arcobacter species. These have been reported from chickens, domestic animals (cattle, pigs, sheep, horses, dogs), reptiles (lizards, snakes and chelonians), meat (poultry, pork, goat, lamb, beef, rabbit), vegetables and from humans in different countries. Arcobacters are implicated as causative agents of diarrhea, mastitis and abortion in animals, while causing bacteremia, endocarditis, peritonitis, gastroenteritis and diarrhea in humans. Three species including A. butzleri, A. cryaerophilus and A. skirrowii are predominantly associated with clinical conditions. Arcobacters are primarily transmitted through contaminated food and water sources. Identification of Arcobacter by biochemical tests is difficult and isolation remains the gold standard method. Current diagnostic advances have provided various molecular methods for efficient detection and differentiation of the Arcobacters at genus and species level. To overcome the emerging antibiotic resistance problem there is an essential need to explore the potential of novel and alternative therapies. Strengthening of the diagnostic aspects is also suggested as in most cases Arcobacters goes unnoticed and hence the exact epidemiological status remains uncertain. This review updates the current knowledge and many aspects of this important food-borne pathogen, namely etiology, evolution and emergence, genetic diversity, epidemiology, the disease in animals and humans, public health concerns, and advances in its diagnosis, prevention and control.