Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci

Microsporidia of the genus are generally connected with severe infections with lethal outcome in immunodeficient hosts. In immunocompetent hosts, microsporidiosis typically establishes a balanced host-parasite relationship that produces minimal clinically overt disease. Although the alimentary tract...

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Bibliographic Details
Published in:Journal of inflammation research 2020-01, Vol.13, p.583-593
Main Authors: Brdíčková, Klára, Sak, Bohumil, Holubová, Nikola, Květoňová, Dana, Hlásková, Lenka, Kicia, Marta, Kopacz, Żaneta, Kváč, Martin
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
Design of experiments
DNA
Encephalitis
encephalitozoon cuniculi
Feces
Gastrointestinal tract
Genetic aspects
Genotype & phenotype
Genotypes
Health aspects
Histology
Immune response
Immunodeficiency
Infection
Infections
Inflammation
Microsporidia
Microsporidiosis
Original Research
Parasites
Severe combined immunodeficiency
Spores
targeted migration
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Summary:Microsporidia of the genus are generally connected with severe infections with lethal outcome in immunodeficient hosts. In immunocompetent hosts, microsporidiosis typically establishes a balanced host-parasite relationship that produces minimal clinically overt disease. Although the alimentary tract represents one of the main primary target tissues, the mechanisms of reaching other tissues during systemic microsporidian infections remain unclear. In the present study, we tested the relation between inflammation induction in immunocompetent and immunodeficient mice and the presence of spores of genotype II in selected organs and in fecal specimens by using molecular and histology methods. We reported the positive connection between inflammation induction and the significant increase of genotype II occurrence in inflammation foci in both immunocompetent BALB/c and immunodeficient severe combined immunodeficient (SCID) mice in the acute phase of infection and the re-activation of latent microsporidial infection following inflammation induction in immunocompetent mice. The results imply possible involvement of immune cells serving as vehicles transporting genotype II purposefully across the whole host body towards inflammation. With increasing number of records of infections, it is necessary to reconsider microsporidia as agents responsible for various pathologies. The elucidation of possible connection with pro-inflammatory immune responses represents an important challenge with consequences for human health and development of therapeutic strategies.
ISSN:1178-7031
1178-7031
DOI:10.2147/JIR.S271628