Vascular Damage in Patients with Nonalcoholic Fatty Liver Disease: Possible Role of Iron and Ferritin

Non Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease in Western countries. Recent data indicated that NAFLD is a risk factor by itself contributing to the development of cardiovascular disease independently of classical known risk factors. Hyperferritinemia and mild inc...

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Bibliographic Details
Published in:International journal of molecular sciences 2016-05, Vol.17 (5), p.675-675
Main Authors: Pisano, Giuseppina, Lombardi, Rosa, Fracanzani, Anna Ludovica
Format: Article
Language:English
Subjects:
cardiovascular disease
ferritin
Ferritins - genetics
Ferritins - metabolism
Humans
iron
Iron - metabolism
metabolic syndrome
Mutation
NAFLD
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - metabolism
Non-alcoholic Fatty Liver Disease - pathology
Plaque, Atherosclerotic - genetics
Plaque, Atherosclerotic - metabolism
Plaque, Atherosclerotic - pathology
Review
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Summary:Non Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease in Western countries. Recent data indicated that NAFLD is a risk factor by itself contributing to the development of cardiovascular disease independently of classical known risk factors. Hyperferritinemia and mild increased iron stores are frequently observed in patients with NAFLD and several mechanisms have been proposed to explain the role of iron, through oxidative stress and interaction with insulin metabolism, in the development of vascular damage. Moreover, iron depletion has been shown to decrease atherogenesis in experimental models and in humans. This review presents the recent evidence on epidemiology, pathogenesis, and the possible explanation of the role of iron and ferritin in the development of cardiovascular damage in patients with NAFLD, and discusses the possible interplay between metabolic disorders associated with NAFLD and iron in the development of cardiovascular disease.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms17050675