Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s

Exaggerated inflammatory responses in microglia represent one of the major risk factors for various central nervous system’s (CNS) associated pathologies. Release of excessive inflammatory mediators such as prostaglandins and cytokines are the hallmark of hyper-activated microglia. Here we have inve...

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Bibliographic Details
Published in:Scientific reports 2017-03, Vol.7 (1), p.116-116, Article 116
Main Authors: Bhatia, Harsharan S., Roelofs, Nora, Muñoz, Eduardo, Fiebich, Bernd L.
Format: Article
Language:English
Subjects:
13/106
13/21
13/95
14/1
14/19
38
38/90
631/378/2596/1953
631/378/371
64
64/60
82
82/29
82/51
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
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Summary:Exaggerated inflammatory responses in microglia represent one of the major risk factors for various central nervous system’s (CNS) associated pathologies. Release of excessive inflammatory mediators such as prostaglandins and cytokines are the hallmark of hyper-activated microglia. Here we have investigated the hitherto unknown effects of capsaicin (cap) - a transient receptor potential vanilloid 1 (TRPV1) agonist- in murine primary microglia, organotypic hippocampal slice cultures (OHSCs) and human primary monocytes. Results demonstrate that cap (0.1–25 µM) significantly (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-00225-5