Hydrogen Peroxide Disinfecting Solution for Gas Permeable Contact Lenses: A Review of the Antimicrobial Efficacy, Compatibility, and Safety Performance of a One-Step Lens Care System

CLEAR CARE PLUS (CCP), also known as AOSEPT PLUS with HydraGlyde, is approved for use with gas permeable (GP) lenses, and the indication is supported by the scientific evidence that is reviewed in this article. Antimicrobial efficacy testing of CCP both as a stand-alone disinfectant and as part of a...

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Bibliographic Details
Published in:Clinical optometry (Auckland) 2021, Vol.13, p.7-14
Main Authors: Gabriel, Manal M, McAnally, Cynthia, Chen, Huagang, Srinivasan, Sruthi, Manoj, Venkiteshwar, Garofalo, Renee
Format: Article
Language:English
Subjects:
Antimicrobial agents
antimicrobial efficacy
aosept plus with hydraglyde
Bacteria
clear care plus
Contact lenses
Cysts
Disinfection & disinfectants
gas permeable contact lenses
Hydrogen peroxide
Infection control
Laboratories
lens care
Medical personnel
Microorganisms
Review
Silicones
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Summary:CLEAR CARE PLUS (CCP), also known as AOSEPT PLUS with HydraGlyde, is approved for use with gas permeable (GP) lenses, and the indication is supported by the scientific evidence that is reviewed in this article. Antimicrobial efficacy testing of CCP both as a stand-alone disinfectant and as part of a regimen shows that CCP exceeds the ISO 14729 criteria against bacteria, yeast, and mold. In real-world conditions, it is effective against clinically relevant bacterial strains isolated from adverse events and against the two forms, trophozoites and cysts, of resilient species. Compatibility tests of CCP with two types of GP lenses indicate that the physical and/or optical parameters of lenses are unaffected through 30 cycles of simulated use with CCP, and a clinical trial shows substantial equivalence of clinical performance with a commonly used GP multipurpose solution. These results indicate that CCP is well suited for cleaning and disinfection of GP contact lenses.
ISSN:1179-2752
1179-2752
DOI:10.2147/OPTO.S280046