Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers

• Published in: International journal of molecular sciences 2021-06, Vol.22 (12), p.6625
• Main Authors: Ermini, Leonardo, Nuzzo, Anna Maria, Ietta, Francesca, Romagnoli, Roberta, Moretti, Laura, Masturzo, Bianca, Paulesu, Luana, Rolfo, Alessandro
• Format: Article
• Language: English
• Subjects: Adipocytes; Adult; Benzhydryl Compounds - toxicity; Bisphenol A; Body mass index; Body weight; BPA; Case-Control Studies; Epoxy resins; Explants; Female; Fetuses; Gene expression; Gestational age; Gestational diabetes; Glucose; Glucose transporter; Glucose Transporter Type 1 - metabolism; Glucose Transporter Type 4 - metabolism; GLUT1; GLUT4; human placenta; human pregnancy; Humans; Metabolism; Obesity; Overweight; Overweight - complications; Overweight - metabolism; Phenols - toxicity; Physiology; Placenta; Placenta - drug effects; Placenta - metabolism; Population; Pregnancy; Pregnancy Complications - chemically induced; Pregnancy Complications - metabolism; Protein expression; Proteins; Womens health
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22126625

Bisphenol A (BPA) is a synthetic phenol extensively used in the manufacture of polycarbonate plastics and epoxy resins and a component of liquid and food storages. Among health disorders potentially attributed to BPA, the effects on metabolism have been especially studied. BPA represents a hazard in prenatal life because of its presence in tissues and fluids during pregnancy. Our recent study in rats fed with BPA showed a placental increase in glucose type 1 transporter (GLUT-1), suggesting a higher uptake of glucose. However, the role of BPA on GLUT transporters in pregnant women with metabolic dysfunction has not yet been investigated. In this study, placental tissue from 26 overweight (OW) women and 32 age-matched normal weight (NW) pregnant women were examined for expression of GLUT1 and GLUT4. Placental explants from OW and NW mothers were exposed to BPA 1 nM and 1 μM and tested for GLUTs expression. The data showed a different response of placental explants to BPA in GLUT1 expression with an increase in NW mothers and a decrease in OW ones. GLUT4 expression was lower in the explants from OW than NW mothers, while no difference was showed between OW and NW in placental biopsies for any of the transporters.