Regulation and Directing Stem Cell Fate by Tissue Engineering Functional Microenvironments: Scaffold Physical and Chemical Cues

It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior...

Full description

Saved in:
Bibliographic Details
Published in:Stem cells international 2019, Vol.2019 (2019), p.1-16
Main Authors: Zhang, Xingdong, Xiang, Zhou, Kong, Qingquan, Lei, Haoyuan, Wu, Lina, Long, Cheng, Zhou, Changchun, Li, Lang, Xing, Fei, Fan, Yujiang
Format: Article
Language:English
Subjects:
3-D printers
Biocompatibility
Biomedical materials
Bones
Cell adhesion
Cell fate
Cell growth
Chemical stimuli
Embryos
Gene expression
Growth factors
Kinases
Mechanical properties
Mechanical stimuli
Methods
Microenvironments
Organic chemistry
Physical factors
Porosity
Researchers
Review
Scaffolds
Stem cells
Stiffness
Tissue engineering
Topography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is well known that stem cells reside within tissue engineering functional microenvironments that physically localize them and direct their stem cell fate. Recent efforts in the development of more complex and engineered scaffold technologies, together with new understanding of stem cell behavior in vitro, have provided a new impetus to study regulation and directing stem cell fate. A variety of tissue engineering technologies have been developed to regulate the fate of stem cells. Traditional methods to change the fate of stem cells are adding growth factors or some signaling pathways. In recent years, many studies have revealed that the geometrical microenvironment played an essential role in regulating the fate of stem cells, and the physical factors of scaffolds including mechanical properties, pore sizes, porosity, surface stiffness, three-dimensional structures, and mechanical stimulation may affect the fate of stem cells. Chemical factors such as cell-adhesive ligands and exogenous growth factors would also regulate the fate of stem cells. Understanding how these physical and chemical cues affect the fate of stem cells is essential for building more complex and controlled scaffolds for directing stem cell fate.
ISSN:1687-966X
1687-9678
DOI:10.1155/2019/2180925