Interface Hepatitis over Grade 2 May Differentiate Chronic Inflammation Associated with CHB from NAFLD in the Early Stage

Background. Patients with chronic hepatitis B (CHB) concomitant with nonalcoholic fatty liver disease (NAFLD) are increasing. Objectives. To identify pathological features that can be used to differentiate between chronic inflammation caused by CHB and that caused by NAFLD. Methods. Patients with CH...

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Bibliographic Details
Published in:Gastroenterology research and practice 2020, Vol.2020 (2020), p.1-7
Main Authors: Yang, Qiao, Fang, Jia-zhui, Wang, Jin, Zhu, Yong-fen, Lv, Fang-fang
Format: Article
Language:English
Subjects:
Antigens
Antiviral agents
Body mass index
Care and treatment
Comparative analysis
Diabetes
Hepatitis
Hepatitis B
Histopathology
Hypertension
Inflammation
Liver diseases
Pathology
Statistical analysis
Ultrasonic imaging
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Summary:Background. Patients with chronic hepatitis B (CHB) concomitant with nonalcoholic fatty liver disease (NAFLD) are increasing. Objectives. To identify pathological features that can be used to differentiate between chronic inflammation caused by CHB and that caused by NAFLD. Methods. Patients with CHB (n=31) needing antiviral treatment, NAFLD (n=50), or CHB-NAFLD (n=51) who underwent biopsy were retrospectively enrolled. Pathological characteristics of chronic inflammation were evaluated using the METAVIR scoring system. The rates of three pathological characteristics were first compared in patients with NAFLD and those with CHB, then compared after fibrosis matching, and were finally compared in CHB-NAFLD patients with different viral loads. Results. The rates of interface hepatitis over grade 2 and fibrosis over grade 2 were significantly higher in the CHB group than in the NAFLD group (100% vs. 4% and 80.6% vs. 22%; both P
ISSN:1687-6121
1687-630X
DOI:10.1155/2020/3584568