The potential predictive value of cardiac mechanics for left ventricular reverse remodelling in dilated cardiomyopathy

Aims Left ventricular reverse remodelling (LVRR) is an important objective of optimal medical management for dilated cardiomyopathy (DCM) patients, as it is associated with favourable long‐term outcomes. Cardiac magnetic resonance (CMR) can comprehensively assess cardiac structure and function. We a...

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Bibliographic Details
Published in:ESC Heart Failure 2023-12, Vol.10 (6), p.3340-3351
Main Authors: Kan, Ao, Fang, Qimin, Li, Shuhao, Liu, Wenying, Tao, Xinwei, Huang, Kaiyao, Hu, Mengyao, Feng, Zhaofeng, Gong, Lianggeng
Format: Article
Language:English
Subjects:
Cardiac magnetic resonance feature tracking
Cardiomyopathy
Cardiovascular disease
Coronary vessels
Dilated cardiomyopathy
Electrocardiography
Heart failure
Normal distribution
Original
Regression analysis
Reproducibility
Reverse remodelling
Strain
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Summary:Aims Left ventricular reverse remodelling (LVRR) is an important objective of optimal medical management for dilated cardiomyopathy (DCM) patients, as it is associated with favourable long‐term outcomes. Cardiac magnetic resonance (CMR) can comprehensively assess cardiac structure and function. We aimed to assess the CMR parameters at baseline and investigate independent variables to predict LVRR in DCM patients. Methods and results Nighty‐eight initially diagnosed DCM patients who underwent CMR and echocardiography examinations at baseline were included. CMR parameters and feature tracking (FT) based left ventricular (LV) global strain (nStrain) and nStrain indexed to LV cardiac mass index (rStrain) were measured. The predictors of LVRR were determined by multivariate logistic regression analyses. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of CMR parameters and were compared by the DeLong test. At a median follow‐up time of 9 [interquartile range, 7–12] months, 35 DCM patients (36%) achieved LVRR. The patients with LVRR had lower LV volume, mass, LGE extent and stroke volume index (LVSVi) and higher left ventricular remodelling index (LVRI), nStrains, rStrains, and peak systolic strain rate (PSSR) in the longitudinal direction and rStrains in the circumferential direction at baseline (all P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.14529