Contribution of tryptophan and its metabolites to transplant outcome: a mini-review

Long-term tolerance in the absence of immunosuppressive drugs is a major goal in the transplantation field, not yet attained. Recent research on the role of commensal microbiota in the control of immunity has opened new avenues for the search of novel clinical interventions. Indeed, products of inte...

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Published in:Frontiers in immunology 2024-10, Vol.15, p.1395421
Main Authors: Donoso-Meneses, Darío, Padilla, Cristina, Moya-Guzmán, María José, Alegre, Maria-Luisa, Pino-Lagos, Karina
Format: Article
Language:English
Subjects:
Animals
Gastrointestinal Microbiome - immunology
Graft Rejection - immunology
Graft Rejection - metabolism
Graft Survival - immunology
Humans
immune regulation
Immunology
microbiota
Organ Transplantation
tolerance
transplantation
Transplantation Tolerance
Treatment Outcome
trypthophan metabolism
Tryptophan - metabolism
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container_title Frontiers in immunology
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creator Donoso-Meneses, Darío
Padilla, Cristina
Moya-Guzmán, María José
Alegre, Maria-Luisa
Pino-Lagos, Karina
description Long-term tolerance in the absence of immunosuppressive drugs is a major goal in the transplantation field, not yet attained. Recent research on the role of commensal microbiota in the control of immunity has opened new avenues for the search of novel clinical interventions. Indeed, products of intestinal metabolism generated by both host cells and the microbiota have been identified as modulators of the immune response. Among these, tryptophan (Trp) and its derivatives are being investigated to understand their impact on alloimmunity and their potential usefulness as therapeutic targets to improve allograft survival. Here, we reviewed the latest findings on the contribution of Trp metabolic pathways to transplant outcomes.
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subjects Animals
Gastrointestinal Microbiome - immunology
Graft Rejection - immunology
Graft Rejection - metabolism
Graft Survival - immunology
Humans
immune regulation
Immunology
microbiota
Organ Transplantation
tolerance
transplantation
Transplantation Tolerance
Treatment Outcome
trypthophan metabolism
Tryptophan - metabolism
title Contribution of tryptophan and its metabolites to transplant outcome: a mini-review
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