Spontaneous regression of small cell lung cancer associated with Lambert-Eaton Myasthenic Syndrome: Case report

Spontaneous regression (SR) of cancer is very rare, especially of small cell lung cancer (SCLC). Recently, an association of paraneoplastic neurological syndrome (PNS) has been reported as a cause of SR of cancer, and onconeural antibodies are a possible factor in the SR of cancer associated with PN...

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Bibliographic Details
Published in:Radiology case reports 2023-11, Vol.18 (11), p.4036-4041
Main Authors: Otani, Michimi, Nishimori, Miki, Iwasa, Hitomi, Iwamura, Mamiko, Izumi, Takayasu, Nakaji, Kosuke, Nitta, Noriko, Miyatake, Kana, Yoshimatsu, Rika, Yamanishi, Tomoaki, Matsumoto, Tomohiro, Osaki, Yasushi, Wada, Noriko, Toi, Makoto, Yamamoto, Marino, Nakatani, Yu, Kubota, Tetsuya, Yamagami, Takuji
Format: Article
Language:English
Subjects:
Case Report
Lambert-Eaton myasthenic syndrome
Small cell lung cancer
Spontaneous regression
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Summary:Spontaneous regression (SR) of cancer is very rare, especially of small cell lung cancer (SCLC). Recently, an association of paraneoplastic neurological syndrome (PNS) has been reported as a cause of SR of cancer, and onconeural antibodies are a possible factor in the SR of cancer associated with PNS. We herein report the first case of SR of SCLC combined with anti-P/Q-type of voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS), a subtype of PNS. This case report suggests that SCLC may be spontaneously reduced by an autoimmune response induced by VGCC antibodies associated with LEMS. Our finding may help elucidate the mechanisms that inhibit tumor growth and cause the regression of tumors.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2023.08.059