Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis

To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality (DC) method. In total, 38 patients with high myopia (HM) (17 males and 21 females), whose binocular refractive diopter were -6.00 to -7.00 D, and 38 health...

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Bibliographic Details
Published in:International journal of ophthalmology 2018-11, Vol.11 (11), p.1814-1820
Main Authors: Hu, Yu-Xiang, He, Jun-Rong, Yang, Bo, Huang, Xin, Li, Yu-Ping, Zhou, Fu-Qing, Xu, Xiao-Xuan, Zhong, Yu-Lin, Wang, Jun, Wu, Xiao-Rong
Format: Article
Language:English
Subjects:
Clinical Research
degree centrality
functional magnetic resonance imaging
high myopia
resting state
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Summary:To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality (DC) method. In total, 38 patients with high myopia (HM) (17 males and 21 females), whose binocular refractive diopter were -6.00 to -7.00 D, and 38 healthy controls (17 males and 21 females), closely matched in age, sex, and education levels, participated in the study. Spontaneous brain activities were evaluated using the voxel-wise DC method. The receiver operating characteristic curve was measured to distinguish patients with HM from healthy controls. Correlation analysis was used to explore the relationship between the observed mean DC values of the different brain areas and the behavioral performance. Compared with healthy controls, HM patients had significantly decreased DC values in the right inferior frontal gyrus/insula, right middle frontal gyrus, and right supramarginal/inferior parietal lobule (
ISSN:2222-3959
2227-4898
DOI:10.18240/ijo.2018.11.13