Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E ( 1 ), in addition to previo...

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Bibliographic Details
Published in:Natural products and bioprospecting 2019-12, Vol.9 (6), p.411-417
Main Authors: Nalin Rathnayake, G. R., Savitri Kumar, N., Jayasinghe, Lalith, Araya, Hiroshi, Fujimoto, Yoshinori
Format: Article
Language:English
Subjects:
Acetic acid
Biomedical and Life Sciences
Bioorganic Chemistry
Dextrose
Endophyte
Endophytes
Food Science
Fungi
Life Sciences
Manilkara zapota
Medicinal Chemistry
Metabolites
Original
Original Article
Pestalotin
Pestalotiopsis
Pestalotiopsis microspora
Pharmacology/Toxicology
Pitholide E
Plant Biochemistry
Plant Sciences
Potatoes
Secondary metabolites
Tyrosol
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Summary:An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E ( 1 ), in addition to previously identified pitholide B ( 2 ), pitholide D ( 3 ), pestalotin (LL-P880α) ( 4 ), PC-2 ( 5 ), LL-P880β ( 6 ), tyrosol ( 7 ) and 4-oxo-4 H -pyran-3-acetic acid ( 8 ). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1 – 5 , 7 and 8 from P. microspora are reported here for the first time. Graphic Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-019-00225-0