Left ventricular myocardial performance index in prediabetic patients without coronary artery disease

Background Prediabetes is considered a major risk factor for diabetes mellitus (DM), leading to microvascular and cardiovascular disorders. Myocardial performance index (MPI) is a non-invasive Doppler method for the determination of global ventricular activity. We have not enough knowledge about the...

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Bibliographic Details
Published in:The Egyptian journal of internal medicine 2021-12, Vol.33 (1), p.28-5, Article 28
Main Authors: Mahmoud, Hossam Eldin M., Alsenbesy, Mohamed, Sayed, Gehad Osama Fawzy, Ali, Abdulla Eliaw Mohamed, Sabra, Ahlam M.
Format: Article
Language:English
Subjects:
Cardiovascular disease
Cholesterol
Creatinine
Diabetes
Ejection fraction
Glucose
Heart
High density lipoprotein
Hypertension
Internal Medicine
Laboratories
Left ventricular function
Lipids
Lipoproteins
Males
Medicine
Medicine & Public Health
Mortality
Myocardial performance index
Patients
Prediabetes
Proteins
Software
Tissue Doppler imaging
Variance analysis
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Summary:Background Prediabetes is considered a major risk factor for diabetes mellitus (DM), leading to microvascular and cardiovascular disorders. Myocardial performance index (MPI) is a non-invasive Doppler method for the determination of global ventricular activity. We have not enough knowledge about the effect of prediabetes on the left ventricular (LV) function. We aimed to assess the MPI in prediabetic patients without coronary artery disease (CAD) utilizing echocardiography tissue Doppler imaging (TDI). Results We conducted a randomized controlled study that included fifty prediabetic patients and fifty healthy participants as the control group. All the participants were subjected to laboratory tests and echocardiography TDI to evaluate the LV systolic and diastolic functions We found that the isovolumic relaxation time (IVRT) and MPI values were significantly increased in the prediabetic patients compared to the control group ( P < 0.001). In contrast, left ventricular ejection time (ET) was significantly longer in the control group than in prediabetic patients. Conclusion Prediabetes may adversely affect the LV function as assessed by MPI. Screening for prediabetes and early intervention is required for the prevention of cardiovascular morbidity and mortality.
ISSN:1110-7782
2090-9098
DOI:10.1186/s43162-021-00063-y